B
Bruce A. Barut
Researcher at Howard Hughes Medical Institute
Publications - 33
Citations - 4804
Bruce A. Barut is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Zebrafish & Positional cloning. The author has an hindex of 24, co-authored 33 publications receiving 4587 citations. Previous affiliations of Bruce A. Barut include Boston Children's Hospital & Harvard University.
Papers
More filters
Journal ArticleDOI
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Adriana Donovan,Alison Brownlie,Alison Brownlie,Yi Zhou,Jennifer L. Shepard,Stephen J. Pratt,John Moynihan,Barry H. Paw,Anna Drejer,Bruce A. Barut,Bruce A. Barut,Agustín G. Zapata,Terence C. Law,Carlo Brugnara,Samuel E. Lux,Geraldine S. Pinkus,Jack L. Pinkus,Paul D. Kingsley,James Palis,Mark D. Fleming,Mark D. Fleming,Nancy C. Andrews,Nancy C. Andrews,Leonard I. Zon,Leonard I. Zon +24 more
TL;DR: The gene responsible for the hypochromic anaemia of the zebrafish mutant weissherbst is identified and Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload.
Journal ArticleDOI
Mitoferrin is essential for erythroid iron assimilation
George C. Shaw,John J. Cope,John J. Cope,Liangtao Li,Kenneth Corson,Candace Hersey,Gabriele E. Ackermann,Babette Gwynn,Amy J. Lambert,Rebecca A. Wingert,Rebecca A. Wingert,David Traver,David Traver,Nikolaus S. Trede,Nikolaus S. Trede,Bruce A. Barut,Yi Zhou,Emmanuel Minet,Adriana Donovan,Alison Brownlie,Rena Balzan,Mitchell J. Weiss,Luanne L. Peters,Jerry Kaplan,Leonard I. Zon,Barry H. Paw +25 more
TL;DR: The data show that mfrn functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts.
Journal ArticleDOI
Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion
TL;DR: The binding of myeloma cells to BMSCs was partially blocked with anti- beta 1 monoclonal antibody (MoAb), anti-beta 2 integrin MoAb, and excess RGD peptide, suggesting multiple mechanisms for the adhesion of myeeloma cell lines to B MSCs.
Journal ArticleDOI
Deficiency of glutaredoxin 5 reveals Fe–S clusters are required for vertebrate haem synthesis
Rebecca A. Wingert,Jenna L. Galloway,Bruce A. Barut,Helen Foott,Paula G. Fraenkel,Jennifer L. Axe,Gerhard J. Weber,Kimberly Dooley,Alan J. Davidson,Bettina Schmidt,Barry H. Paw,Barry H. Paw,George C. Shaw,George C. Shaw,Paul D. Kingsley,James Palis,Heidi L. Schubert,Opal S. Chen,Jerry Kaplan,Leonard I. Zon +19 more
TL;DR: It is shown that the hypochromic anaemia in shiraz (sir) zebrafish mutants is caused by deficiency of glutaredoxin 5 (grx5), a gene required in yeast for Fe–S cluster assembly, indicating that haemoglobin production in the differentiating red cell is regulated through Fe– S cluster assembly.
Journal ArticleDOI
Response patterns of purified myeloma cells to hematopoietic growth factors.
TL;DR: The heterogeneity in the in vitro responses of myeloma cells and derived cell lines to exogenous growth factors enhances the understanding of abnormal plasma cell growth and may yield insight into the pathophysiology of plasma cell dyscrasias.