Journal ArticleDOI
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.
TLDR
Structural and functional aspects of FBW7, the substrate recognition component of an evolutionary conserved SCF, and its role in the development of cancer are focused on.Abstract:
FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase. SCF(FBW7) degrades several proto-oncogenes that function in cellular growth and division pathways, including MYC, cyclin E, Notch and JUN. FBW7 is also a tumour suppressor, the regulatory network of which is perturbed in many human malignancies. Numerous cancer-associated mutations in FBW7 and its substrates have been identified, and loss of FBW7 function causes chromosomal instability and tumorigenesis. This Review focuses on structural and functional aspects of FBW7 and its role in the development of cancer.read more
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Reflecting on 25 years with MYC
Natalie Meyer,Linda Z. Penn +1 more
TL;DR: Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified and each incremental insight into MYC regulation and function has had an impact on numerous biological disciplines, including the understanding of molecular oncogenesis in general.
Journal ArticleDOI
Genome remodelling in a basal-like breast cancer metastasis and xenograft
Li Ding,Matthew J. Ellis,Shunqiang Li,David E. Larson,Ken Chen,John W. Wallis,Chris Harris,Michael D. McLellan,Robert S. Fulton,Lucinda Fulton,Rachel Abbott,Jeremy Hoog,David J. Dooling,Daniel C. Koboldt,Heather K. Schmidt,Joelle Kalicki,Qunyuan Zhang,Lei Chen,Ling Lin,Michael C. Wendl,Joshua F. McMichael,Vincent Magrini,Lisa Cook,Sean McGrath,Tammi L. Vickery,Elizabeth L. Appelbaum,Katherine DeSchryver,Sherri R. Davies,Therese Guintoli,Li-li Lin,Robert J. Crowder,Yu Long Tao,Jacqueline E. Snider,Scott M. Smith,Adam F. Dukes,Gabriel E. Sanderson,Craig Pohl,Kim D. Delehaunty,Catrina Fronick,Kimberley A. Pape,Jerry S. Reed,Jody S. Robinson,Jennifer S. Hodges,William Schierding,Nathan D. Dees,Dong-Wei Shen,Devin P. Locke,Madeline E. Wiechert,James M. Eldred,Josh B. Peck,Benjamin J. Oberkfell,Justin T. Lolofie,Feiyu Du,Amy Hawkins,Michelle D O'Laughlin,Kelly E. Bernard,Mark L. Cunningham,Glendoria Elliott,Mark D. Mason,Dominic M. Thompson,Jennifer Ivanovich,Paul J. Goodfellow,Charles M. Perou,George M. Weinstock,Rebecca Aft,Mark A. Watson,Timothy J. Ley,Richard K. Wilson,Elaine R. Mardis +68 more
TL;DR: The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared with the primary tumour indicate that secondary tumours may arise from a minority of cells within thePrimary tumour.
Journal ArticleDOI
Global signatures of protein and mRNA expression levels
TL;DR: This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters.
Journal ArticleDOI
Myc's broad reach.
Martin Eilers,Robert N. Eisenman +1 more
TL;DR: The nature of the genes and pathways that are targeted by Myc, and the role of Myc in stem cell and cancer biology are reviewed.
Journal ArticleDOI
The multifaceted roles of fatty acid synthesis in cancer
Florian Röhrig,Almut Schulze +1 more
TL;DR: This Review explores how different aspects of FA synthesis promote tumorigenesis and tumour progression and strategies to target this pathway have not yet translated into clinical practice.
References
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Journal ArticleDOI
Notch Signaling: Cell Fate Control and Signal Integration in Development
TL;DR: Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.
Journal ArticleDOI
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more
TL;DR: These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling.
Journal ArticleDOI
AP-1 as a regulator of cell life and death
Eitan Shaulian,Michael Karin +1 more
TL;DR: Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect.
Journal ArticleDOI
PI3K/Akt signalling pathway and cancer ☆
Juan Ángel Fresno Vara,Enrique Casado,Javier de Castro,Paloma Cejas,Cristobal Belda-Iniesta,Manuel González-Barón +5 more
TL;DR: The PI3K/Akt pathway is involved in many of the mechanisms targeted by these new drugs, thus a better understanding of this crossroad can help to fully exploit the potential benefits of these new agents.
Journal ArticleDOI
Genetic Control of the Cell Division Cycle in Yeast
TL;DR: Two features which distinguish the cell cycle of Saccharomyces cerevisiae from most other eukaryotes are particularly useful for an analysis of the gene functions that control the cell division cycle.