C
C. Megan Young
Researcher at Cold Spring Harbor Laboratory
Publications - 2
Citations - 919
C. Megan Young is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Enhancer & Pioneer factor. The author has an hindex of 2, co-authored 2 publications receiving 597 citations. Previous affiliations of C. Megan Young include Lustgarten Foundation & École Polytechnique Fédérale de Lausanne.
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Organoid profiling identifies common responders to chemotherapy in pancreatic cancer
Hervé Tiriac,Pascal Belleau,Dannielle D. Engle,Dennis Plenker,Astrid Deschênes,Tim D.D. Somerville,Fieke E. M. Froeling,Richard A. Burkhart,Robert E. Denroche,Gun-Ho Jang,Koji Miyabayashi,C. Megan Young,C. Megan Young,Hardik Patel,Michelle Ma,Joseph F. LaComb,Randze Lerie Palmaira,Ammar A. Javed,Jasmine Huynh,Molly E. Johnson,Kanika Arora,Nicolas Robine,Minita Shah,Rashesh Sanghvi,Austin Goetz,Cinthya Y. Lowder,Laura A. Martello,Else Driehuis,Nicolas Lecomte,Gokce Askan,Christine A. Iacobuzio-Donahue,Hans Clevers,Laura D. Wood,Ralph H. Hruban,Elizabeth D. Thompson,Andrew J. Aguirre,Brian M. Wolpin,Aaron R. Sasson,Joseph Kim,Maoxin Wu,Juan Carlos Bucobo,Peter J. Allen,Divyesh V. Sejpal,William Nealon,James Sullivan,Jordan M. Winter,Phyllis A. Gimotty,Jean L. Grem,Dominick J. DiMaio,Jonathan M. Buscaglia,Paul M. Grandgenett,Jonathan R. Brody,Michael A. Hollingsworth,Grainne M. O'Kane,Faiyaz Notta,Edward J. Kim,James M. Crawford,Craig Devoe,Allyson J. Ocean,Christopher L. Wolfgang,Kenneth H. Yu,Ellen Li,Christopher R. Vakoc,Benjamin Hubert,Sandra Fischer,Sandra Fischer,Julie M. Wilson,Richard A. Moffitt,Jennifer J. Knox,Alexander Krasnitz,Steven Gallinger,Steven Gallinger,Steven Gallinger,David A. Tuveson +73 more
TL;DR: A pancreatic cancer patient-derived organoid (PDO) library is generated that recapitulates the mutational spectrum and transcriptional subtypes of primary Pancreatic cancer and proposes that combined molecular and therapeutic profiling of PDOs may predict clinical response and enable prospective therapeutic selection.
Journal ArticleDOI
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis
Jae Seok Roe,Chang-Il Hwang,Chang-Il Hwang,Tim D.D. Somerville,Joseph P. Milazzo,Eun Jung Lee,Eun Jung Lee,Brandon Da Silva,Brandon Da Silva,Laura Maiorino,Hervé Tiriac,Hervé Tiriac,C. Megan Young,C. Megan Young,Koji Miyabayashi,Koji Miyabayashi,Dea Filippini,Dea Filippini,Brianna Creighton,Brianna Creighton,Richard A. Burkhart,Jonathan M. Buscaglia,Edward J. Kim,Jean L. Grem,Audrey J. Lazenby,James A. Grunkemeyer,Michael A. Hollingsworth,Paul M. Grandgenett,Mikala Egeblad,Young-Kyu Park,Young-Kyu Park,David A. Tuveson,David A. Tuveson,Christopher R. Vakoc +33 more
TL;DR: This study used an organoid culture system to investigate how transcription and the enhancer landscape become altered during discrete stages of disease progression in a PDA mouse model, and revealed that the metastatic transition is accompanied by massive and recurrent alterations in enhancer activity.