D
Dennis Plenker
Researcher at Cold Spring Harbor Laboratory
Publications - 13
Citations - 929
Dennis Plenker is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 6, co-authored 13 publications receiving 514 citations. Previous affiliations of Dennis Plenker include Lustgarten Foundation.
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Journal ArticleDOI
Organoid profiling identifies common responders to chemotherapy in pancreatic cancer
Hervé Tiriac,Pascal Belleau,Dannielle D. Engle,Dennis Plenker,Astrid Deschênes,Tim D.D. Somerville,Fieke E. M. Froeling,Richard A. Burkhart,Robert E. Denroche,Gun-Ho Jang,Koji Miyabayashi,C. Megan Young,C. Megan Young,Hardik Patel,Michelle Ma,Joseph F. LaComb,Randze Lerie Palmaira,Ammar A. Javed,Jasmine Huynh,Molly E. Johnson,Kanika Arora,Nicolas Robine,Minita Shah,Rashesh Sanghvi,Austin Goetz,Cinthya Y. Lowder,Laura A. Martello,Else Driehuis,Nicolas Lecomte,Gokce Askan,Christine A. Iacobuzio-Donahue,Hans Clevers,Laura D. Wood,Ralph H. Hruban,Elizabeth D. Thompson,Andrew J. Aguirre,Brian M. Wolpin,Aaron R. Sasson,Joseph Kim,Maoxin Wu,Juan Carlos Bucobo,Peter J. Allen,Divyesh V. Sejpal,William Nealon,James Sullivan,Jordan M. Winter,Phyllis A. Gimotty,Jean L. Grem,Dominick J. DiMaio,Jonathan M. Buscaglia,Paul M. Grandgenett,Jonathan R. Brody,Michael A. Hollingsworth,Grainne M. O'Kane,Faiyaz Notta,Edward J. Kim,James M. Crawford,Craig Devoe,Allyson J. Ocean,Christopher L. Wolfgang,Kenneth H. Yu,Ellen Li,Christopher R. Vakoc,Benjamin Hubert,Sandra Fischer,Sandra Fischer,Julie M. Wilson,Richard A. Moffitt,Jennifer J. Knox,Alexander Krasnitz,Steven Gallinger,Steven Gallinger,Steven Gallinger,David A. Tuveson +73 more
TL;DR: A pancreatic cancer patient-derived organoid (PDO) library is generated that recapitulates the mutational spectrum and transcriptional subtypes of primary Pancreatic cancer and proposes that combined molecular and therapeutic profiling of PDOs may predict clinical response and enable prospective therapeutic selection.
Journal ArticleDOI
Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes
Koji Miyabayashi,Koji Miyabayashi,Lindsey A. Baker,Lindsey A. Baker,Astrid Deschênes,Astrid Deschênes,Benno Traub,Benno Traub,Giuseppina Caligiuri,Giuseppina Caligiuri,Dennis Plenker,Dennis Plenker,Brinda Alagesan,Brinda Alagesan,Pascal Belleau,Siran Li,Jude Kendall,Gun Ho Jang,Gun Ho Jang,Gun Ho Jang,Risa Karakida Kawaguchi,Tim D.D. Somerville,Hervé Tiriac,Hervé Tiriac,Hervé Tiriac,Chang-Il Hwang,Chang-Il Hwang,Chang-Il Hwang,Richard A. Burkhart,Nicholas J. Roberts,Nicholas J. Roberts,Laura D. Wood,Laura D. Wood,Ralph H. Hruban,Ralph H. Hruban,Jesse Gillis,Alexander Krasnitz,Christopher R. Vakoc,Michael Wigler,Faiyaz Notta,Faiyaz Notta,Faiyaz Notta,Steven Gallinger,Young-Kyu Park,Young-Kyu Park,David A. Tuveson,David A. Tuveson +46 more
TL;DR: A xenotransplantation model of PDAC is presented in which neoplasms originate from patient-derived organoids injected directly into murine pancreatic ducts and a suite of RAS-regulated secreted and membrane bound proteins are identified which may represent potential candidates for therapeutic intervention in PDAC patients.
Journal ArticleDOI
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
Stephan Dreyer,Rosie Upstill-Goddard,Viola Paulus-Hock,Clara Paris,Eirini Lampraki,Eloise Dray,Bryan Serrels,Giuseppina Caligiuri,Selma Rebus,Dennis Plenker,Zachary C. Galluzzo,Holly Brunton,Richard Cunningham,Mathias Tesson,Craig Nourse,Ulla-Maja Bailey,D. Marc Jones,Kim Moran-Jones,Derek W. Wright,Fraser Duthie,Karin A. Oien,Lisa Evers,Colin J. McKay,Grant A. McGregor,Aditi Gulati,Rachel Brough,Ilirjana Bajrami,Stephan Pettitt,Michele L. Dziubinski,Juliana Candido,Frances R. Balkwill,Simon T. Barry,Robert Grützmann,Lola Rahib,Amber L. Johns,Marina Pajic,Fieke E. M. Froeling,Phillip Beer,Elizabeth A. Musgrove,Gloria M. Petersen,Alan Ashworth,Margaret C. Frame,Howard C. Crawford,Diane M. Simeone,Christopher J. Lord,Debabrata Mukhopadhyay,Christian Pilarsky,David A. Tuveson,Susanna L. Cooke,Nigel B. Jamieson,Jennifer P. Morton,Owen J. Sansom,Peter Bailey,Andrew V. Biankin,David K. Chang +54 more
TL;DR: Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR-proficient PC and after platinum therapy.
Journal ArticleDOI
Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer.
Toni T. Seppälä,Jacquelyn W. Zimmerman,Elisabetta Sereni,Dennis Plenker,Reecha Suri,Noah Rozich,Alex B. Blair,Dwayne L. Thomas,Jonathan Teinor,Ammar A. Javed,Hardik Patel,John L. Cameron,William R. Burns,Jin He,David A. Tuveson,Elizabeth M. Jaffee,James R. Eshleman,Annamaria Szabolcs,David P. Ryan,David T. Ting,Christopher L. Wolfgang,Richard A. Burkhart +21 more
TL;DR: Rapid development of PDOs from patients undergoing surgery for PDAC is eminently feasible within the perioperative recovery period, enabling the potential for pharmacotyping to guide postoperative adjuvant chemotherapeutic selection.
Journal ArticleDOI
Organoid models for translational pancreatic cancer research.
TL;DR: Pancreatic ductal organoids are ex-vivo models of PDAC that can be established from very small biopsies, enabling the study of localized, advanced, and metastatic patients.