Cansu Cimen Bozkus

TL;DR: The current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death are summarized.

TL;DR: This study uncovers the widespread occurrence and strong immunogenicity of tumor-specific antigens derived from shared frameshift mutations in MSI-H cancer and Lynch syndrome patients, suitable for the design of common "off-the-shelf" cancer vaccines.

TL;DR: It is demonstrated that cationic amino acid transporter 2 (Cat2), coordinately with Arg1 and Nos2, contributes to the transport of l-Arg in MDSCs and is an important regulator of MDSC suppressive function.

TL;DR: This article reported the first HLA-I immunopeptidome of SARS-CoV-2 in two cell lines at different times post infection using mass spectrometry and found HLAI peptides derived not only from canonical open reading frames (ORFs) but also from internal out-of-frame ORFs in spike and nucleocapsid not captured by current vaccines.

TL;DR: It is demonstrated that while a subset of CALR+ MPN patients develops specific T cell responses against mut-CALR C-terminus, programmed cell death protein 1 (PD-1) or cytotoxic T lymphocyte antigen 4 (CTLA-4) expression abrogates the full complement of responses.