C
Carlo Brugnara
Researcher at Boston Children's Hospital
Publications - 348
Citations - 20837
Carlo Brugnara is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Red blood cell & Iron deficiency. The author has an hindex of 76, co-authored 333 publications receiving 19351 citations. Previous affiliations of Carlo Brugnara include Albert Einstein College of Medicine & University of Kansas.
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Journal ArticleDOI
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Adriana Donovan,Alison Brownlie,Alison Brownlie,Yi Zhou,Jennifer L. Shepard,Stephen J. Pratt,John Moynihan,Barry H. Paw,Anna Drejer,Bruce A. Barut,Bruce A. Barut,Agustín G. Zapata,Terence C. Law,Carlo Brugnara,Samuel E. Lux,Geraldine S. Pinkus,Jack L. Pinkus,Paul D. Kingsley,James Palis,Mark D. Fleming,Mark D. Fleming,Nancy C. Andrews,Nancy C. Andrews,Leonard I. Zon,Leonard I. Zon +24 more
TL;DR: The gene responsible for the hypochromic anaemia of the zebrafish mutant weissherbst is identified and Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload.
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Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice: A Direct Role for Stat5 in Bcl-XL Induction
TL;DR: It is shown that Stat5 is essential for the high erythropoietic rate during fetal development, explained by a crucial role for Stat5 in EpoR's antiapoptotic signaling: it mediates the immediate-early induction of Bcl-X(L) in erythroid cells through direct binding to the B cl-X promoter.
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Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts.
Merav Socolovsky,Hyung-song Nam,Mark D. Fleming,Volker H. Haase,Carlo Brugnara,Harvey F. Lodish +5 more
TL;DR: It is shown that some adult Stat5a (-/-)5b(-/-) mice have a near-normal hematocrit but are deficient in generating high erythropoietic rates in response to stress, and many adult Stat 5a-5b-5a mice have persistent anemia despite a marked compensatory expansion in their erythroblast tissue.
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Iron Deficiency and Erythropoiesis: New Diagnostic Approaches
TL;DR: The ratio of serum transferrin receptor to serum ferritin (R/F ratio) has been shown to have excellent performance in estimating body iron stores, but it cannot be used widely because of the lack of standardization for sTfR assays.
Journal ArticleDOI
Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: Role of membrane oxidative damage
Lucia De Franceschi,Giovanna Fattovich,Franco Turrini,Kodjo Ayi,Carlo Brugnara,Franco Manzato,Franco Noventa,Anna Maria Stanzial,Pietro Solero,Roberto Corrocher +9 more
TL;DR: In vivo, RBV‐treated patients showed an increase in aggregated band 3, which was associated with a significantly increased binding of autologous antibodies and complement C3 fragments indicating an erithrophagocytic removal by reticuloendothelial system, suggesting the presence of red cell susceptibility to oxidation.