C
Carlos A. Guzmán
Researcher at University of Genoa
Publications - 281
Citations - 10481
Carlos A. Guzmán is an academic researcher from University of Genoa. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 54, co-authored 260 publications receiving 9506 citations. Previous affiliations of Carlos A. Guzmán include Hannover Medical School & Bill & Melinda Gates Foundation.
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Systems immunology reveals the molecular mechanisms of heterogeneous influenza vaccine response in the elderly
Martijn Zoodsma,Nancy Nguyen,Rodobaldo Pedroso,Stephanie Trittel,Peggy Riese,L. Zhou,Ahmed Alaswad,Hafiz Umar Arshad,Mihai G. Netea,C. J. Xu,Frank Pessler,Carlos A. Guzmán,Lutu Ima Viana da Graca,Y. Li +13 more
TL;DR: In this paper , the authors investigated a cohort of 234 elderly influenza vaccinees across two independent seasons including up to six modalities (multi-omics and immunological parameters) and found that responders exhibited time-dependent changes attributed to a productive vaccine response across all omics layers whereas non-responders did not follow such dynamics, suggestive of systemic dysregulation.