C
Carlos A. Guzmán
Researcher at University of Genoa
Publications - 281
Citations - 10481
Carlos A. Guzmán is an academic researcher from University of Genoa. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 54, co-authored 260 publications receiving 9506 citations. Previous affiliations of Carlos A. Guzmán include Hannover Medical School & Bill & Melinda Gates Foundation.
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Cyclic di‐nucleotides: new era for small molecules as adjuvants
TL;DR: The cyclic di‐nucleotides, which are ubiquitous prokaryotic intracellular signalling molecules, are focused on their potential for the development of vaccines and immunotherapies.
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Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices.
Simone Switalla,L. Lauenstein,Frauke Prenzler,S. Knothe,Christine Förster,Hans-Gerd Fieguth,Olaf Pfennig,Frank Schaumann,Christian Martin,Carlos A. Guzmán,Thomas Ebensen,Meike Müller,Jens M. Hohlfeld,Norbert Krug,Armin Braun,Katherina Sewald +15 more
TL;DR: This work compared the effects of LPS and BPPcysMPEG on the innate immune response in human precision-cut lung slices and found a significant reduction of GM-CSF, IL-1β, and IFN-γ in viable PCLS.
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A Second Two-Component Regulatory System of Bordetella bronchiseptica Required for Bacterial Resistance to Oxidative Stress, Production of Acid Phosphatase, and In Vivo Persistence
TL;DR: Determination of β-galactosidase activity under different environmental conditions suggested that ris is regulated independently of bvg and is optimally expressed at 37°C, in the absence of Mg2+, and when bacteria are in the intracellular niche, suggesting that ris-regulated products play a significant role in natural infections.
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Salmonella vaccine carrier strains: effective delivery system to trigger anti‐tumor immunity by oral route
TL;DR: Oral immunization with both vaccine prototypes resulted in the elicitation of β‐gal‐specific humoral and cell‐mediated immunity, and responses were more efficient when the expression was controlled by the promoter activated upon infection.
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Cohort Study of Airway Mycobiome in Adult Cystic Fibrosis Patients: Differences in Community Structure between Fungi and Bacteria Reveal Predominance of Transient Fungal Elements
Rolf Kramer,Annette Sauer-Heilborn,Tobias Welte,Carlos A. Guzmán,Wolf-Rainer Abraham,Manfred G. Höfle +5 more
TL;DR: F fungi have low colonization abilities in CF, and colonization by pathogenic fungal species may be considered a rare event, which may offer the opportunity to prevent colonization and substantially reduce or even eliminate fungus-related disease progression in CF.