C
Carlos A. Guzmán
Researcher at University of Genoa
Publications - 281
Citations - 10481
Carlos A. Guzmán is an academic researcher from University of Genoa. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 54, co-authored 260 publications receiving 9506 citations. Previous affiliations of Carlos A. Guzmán include Hannover Medical School & Bill & Melinda Gates Foundation.
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Identification of B- and T-cell epitopes within the fibronectin-binding domain of the SfbI protein of Streptococcus pyogenes.
TL;DR: Results suggest that this fibronectin-binding repeats of the SfbI protein of Streptococcus pyogenes constitute the minimal domain able to confer protection against lethal infection and may be suitable for incorporation into a polyepitope-based vaccine formulation against S. pyogene.
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Construction and characterisation of Salmonella typhimurium aroA simultaneously expressing the five pertussis toxin subunits.
TL;DR: Despite a statistically significant anti-PT serum antibody response in immunised mice, vaccination with S. typhimurium aroA (pDP16) failed to protect mice from virulent challenge, and induction of the synthetic PT operon decreased the in vitro invasiveness of S. Typhoon A, compared to vector-only and plasmid-less strains.
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Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants
Tanvi Khera,Patrick Behrendt,Dorothea Bankwitz,Richard J. C. Brown,Daniel Todt,Daniel Todt,Mandy Doepke,Abdul Ghafoor Khan,Kai Schulze,John Lok Man Law,Michael Logan,Darren Hockman,Jason Wong,Leona Dold,Víctor González-Motos,Ulrich Spengler,Abel Viejo-Borbolla,Luisa J Ströh,Thomas Krey,Alexander W. Tarr,Eike Steinmann,Eike Steinmann,Michael P. Manns,Florian Klein,Carlos A. Guzmán,Joseph Marcotrigiano,Michael Houghton,Thomas Pietschmann +27 more
TL;DR: Viruses lacking the HVR1 and selected glycosylation sites expose the CD81 binding site and cross-neutralization antibody epitopes suggesting that exposure of conserved epitopes is not sufficient to focus antibody responses on production of cross- neutralizing antibodies.
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Activated NKT cells imprint NK‐cell differentiation, functionality and education
Peggy Riese,Stephanie Trittel,Tobias May,Luka Cicin-Sain,Benedict J. Chambers,Carlos A. Guzmán +5 more
TL;DR: It is demonstrated that NKT‐cell stimulation induced the generation of highly functional educated and uneducated NK cells, crucial players in viral control in a mCMV infection model.
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A novel escherichia coli expression-export vector containing alkaline phosphatase as an insertional inactivation screening system
TL;DR: An Escherichia coli expression-export vector was constructed containing the alkaline phosphatase structural gene (phoA) located downstream from the phage lambda pR and pL promoters positioned in tandem and the cIts857 gene encoding lambda thermosensitive repressor.