C
Carlos A. Guzmán
Researcher at University of Genoa
Publications - 281
Citations - 10481
Carlos A. Guzmán is an academic researcher from University of Genoa. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 54, co-authored 260 publications receiving 9506 citations. Previous affiliations of Carlos A. Guzmán include Hannover Medical School & Bill & Melinda Gates Foundation.
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Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV
Anusara Daenthanasanmak,Gustavo Salguero,Bala Sai Sundarasetty,Claudia Waskow,Kadriye Nehir Cosgun,Carlos A. Guzmán,Peggy Riese,Laura Gerasch,Andreas Schneider,Alexandra Ingendoh,Martin Messerle,Ildar Gabaev,Benno Woelk,Eliana Ruggiero,Manfred Schmidt,Christof von Kalle,Constanca Figueiredo,Britta Eiz-Vesper,Constantin von Kaisenberg,Arnold Ganser,Renata Stripecke +20 more
TL;DR: A tricistronic integrase-defective lentiviral vector capable to directly induce self-differentiation of PB and CB monocytes into dendritic cells processing pp65 is validated and supports future clinical development of SmyleDCpp65.
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Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge.
Xiaoyan Zheng,Jennifer D. Oduro,Julia D. Boehme,Lisa Borkner,Thomas Ebensen,Ulrike Heise,Marcus Gereke,Marina C. Pils,Astrid Krmpotić,Carlos A. Guzmán,Dunja Bruder,Luka Cicin-Sain +11 more
TL;DR: Results showed that locally applied MCMV vectors could induce mucosal immunity at sites of entry, providing superior immune protection against respiratory infections.
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Simian immunodeficiency virus and human immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate B cell growth.
Francesca Caccuri,Cinzia Giagulli,Joachim Reichelt,Debora Martorelli,Stefania Marsico,Antonella Bugatti,Ines Barone,Marco Rusnati,Carlos A. Guzmán,Riccardo Dolcetti,Arnaldo Caruso +10 more
TL;DR: The findings suggest the appearance of a structural constraint in the p17 C terminus that controls B cell growth, which may help to elucidate the evolutionary trajectory of HIV-1.
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Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway.
Darío Lirussi,Thomas Ebensen,Kai Schulze,Stephanie Trittel,Verónica Durán,Ines Liebich,Ulrich Kalinke,Carlos A. Guzmán +7 more
TL;DR: It is shown here that type I IFN (and not TNF-α) is essential for CDA-mediated cross-presentation by a cathepsin independent, TAP and proteosome dependent cytosolic antigen processing pathway, which promotes effective cross-priming and further CTL induction.
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Modified Vaccinia Virus Ankara Exerts Potent Immune Modulatory Activities in a Murine Model
TL;DR: It is shown that dendritic cells infected in vitro with non-recombinant (nr) MVA expressed maturation and activation markers and were able to efficiently present exogenously pulsed Ag to T cells, opening new ways to potentiate and modulate the immune responses to vaccine Ags depending on whether they are co-administered with MVA or encoded by recombinant viruses.