C
Carlos A. Guzmán
Researcher at University of Genoa
Publications - 281
Citations - 10481
Carlos A. Guzmán is an academic researcher from University of Genoa. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 54, co-authored 260 publications receiving 9506 citations. Previous affiliations of Carlos A. Guzmán include Hannover Medical School & Bill & Melinda Gates Foundation.
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Journal ArticleDOI
In Silico Vaccine Strain Prediction for Human Influenza Viruses
TL;DR: Computational techniques should already be incorporated into the vaccine-selection process in an independent, parallel track, and their performance continuously evaluated.
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Interaction of Salmonella enterica serotype Typhimurium with dendritic cells is defined by targeting to compartments lacking lysosomal membrane glycoproteins.
TL;DR: The capacity of serotype Typhimurium to survive within the established mouse DC line CB1 is shown and it is shown that the PhoPQ two-component regulatory system is not essential for pathogen intracellular survival.
Journal ArticleDOI
Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level.
Cinzia Giagulli,Miriam Noerder,Manuela Avolio,Pablo D. Becker,Simona Fiorentini,Carlos A. Guzmán,Arnaldo Caruso +6 more
TL;DR: Pidotimod is demonstrated to induce DC maturation and up-regulate the expression of HLA-DR and co-stimulatory molecules CD83 and CD86, which are fundamental for communication with adaptative immunity cells, and to promote an effective mucosal and systemic immune response.
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A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects.
Annett Ziegler,Claudia Soldner,Stefan Lienenklaus,Julia Spanier,Stephanie Trittel,Peggy Riese,Thomas Kramps,Siegfried Weiss,Regina Heidenreich,Edith Jasny,Carlos A. Guzmán,Karl-Josef Kallen,Mariola Fotin-Mleczek,Ulrich Kalinke +13 more
TL;DR: Vaccinating mice with an influenza subunit vaccine with RNAdjuvant significantly enhanced this IgG1 and additionally promoted the formation of IgG2b/c, which is indicative of Th1 responses, and upon vaccination with virus-like particles displaying vesicular stomatitis virus G protein, mice were protected against lethal virus infection.
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Dendritic Cell–Mediated Immune Humanization of Mice: Implications for Allogeneic and Xenogeneic Stem Cell Transplantation
Gustavo Salguero,Anusara Daenthanasanmak,Christian Münz,Ana Raykova,Carlos A. Guzmán,Peggy Riese,Constanca Figueiredo,Florian Länger,Andreas Schneider,Laura Macke,Bala Sai Sundarasetty,Torsten Witte,Arnold Ganser,Renata Stripecke +13 more
TL;DR: Adoptive immunotherapy with engineered DC provides a novel strategy for de novo immune reconstitution after human HCT and a practical and effective tool for studying human lymphatic regeneration in vivo in immune deficient xenograft hosts.