C
Carlos A. Guzmán
Researcher at University of Genoa
Publications - 281
Citations - 10481
Carlos A. Guzmán is an academic researcher from University of Genoa. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 54, co-authored 260 publications receiving 9506 citations. Previous affiliations of Carlos A. Guzmán include Hannover Medical School & Bill & Melinda Gates Foundation.
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Journal ArticleDOI
HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype
Simona Fiorentini,Elena Riboldi,Fabio Facchetti,Manuela Avolio,Marco Fabbri,Giorgio Tosti,Pablo D. Becker,Carlos A. Guzmán,Silvano Sozzani,Arnaldo Caruso +9 more
TL;DR: It is shown that peripheral blood p DCs express p17Rs on their surface and that freshly isolated pDCs are sensitive to p17 stimulation, and a model where p17 induces immature circulating pDC's to home in lymph nodes devoid of their ability to serve as a link between innate and adaptative immune systems is proposed.
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Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence.
Nicholas P. West,Heidrun Jungnitz,John T. Fitter,Jason D. McArthur,Carlos A. Guzmán,Mark J. Walker +5 more
TL;DR: The inability to produce wild-type LPS resulted in a reduced bacterial resistance to oxidative stress and a higher susceptibility to the antimicrobial peptide cecropin P. bronchiseptica.
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Dual role colonization factors connecting Vibrio cholerae's lifestyles in human and aquatic environments open new perspectives for combating infectious diseases
TL;DR: It is suggested that DRCFs and, more generally, bacterial factors and pathways having roles in pathogenesis and in the out of the human body life may be promising targets for development of novel prophylactic or therapeutic interventions that may also affect V. cholerae fitness in its environmental reservoirs.
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Attenuated Listeria monocytogenes carrier strains can deliver an HIV-1 gp120 T helper epitope to MHC class II-restricted human CD4+ T cells.
Carlos A. Guzmán,Daniele Saverino,Eva Medina,Daniela Fenoglio,Birgit Gerstel,Andrea Merlo,Giuseppina Li Pira,Francesca Buffa,Trinad Chakraborty,Fabrizio Manca +9 more
TL;DR: It is demonstrated that after ingestion of L. monocytogenes expressing a T helper epitope from the gp120 envelope glycoprotein of HIV, human adherent macrophages and dendritic cells can process and present the epitope to a specific CD4+ T cell line in the context of MHC class II molecules.
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Vaccine adjuvants: key tools for innovative vaccine design.
TL;DR: The present review is focused on vaccine adjuvants approved for human vaccines and promising candidates which are currently under development, together with their strengths, limitations and regulatory framework.