C
Carlos A. Guzmán
Researcher at University of Genoa
Publications - 281
Citations - 10481
Carlos A. Guzmán is an academic researcher from University of Genoa. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 54, co-authored 260 publications receiving 9506 citations. Previous affiliations of Carlos A. Guzmán include Hannover Medical School & Bill & Melinda Gates Foundation.
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Journal ArticleDOI
Opacity Factor Activity and Epithelial Cell Binding by the Serum Opacity Factor Protein of Streptococcus pyogenes Are Functionally Discrete
Christine M. Gillen,Harry S. Courtney,Kai Schulze,Manfred Rohde,Mark R. Wilson,Anjuli M. Timmer,Carlos A. Guzmán,Victor Nizet,Gursharan S. Chhatwal,Mark J. Walker +9 more
TL;DR: In this article, the authors demonstrate that while the N terminus of SOF does not directly mediate intracellular uptake by epithelial cells, this domain enhances epithelial cell uptake mediated by full-length SOF, in comparison to the FnBD alone.
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Stimulation of long-lasting protection against Streptococcus pyogenes after intranasal vaccination with non adjuvanted fibronectin-binding domain of the SfbI protein
TL;DR: It is demonstrated that vaccination with the H12 fragment stimulates long-lasting protective immunity and the adjuvant properties exhibited by the fibronectin-binding domain of the SfbI protein strength the potential of this antigen for inclusion in multi-component vaccines against S. pyogenes.
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The Mucosal Adjuvant Cyclic di-AMP Exerts Immune Stimulatory Effects on Dendritic Cells and Macrophages
Ivana Škrnjug,Christine Rueckert,Rimma Libanova,Stefan Lienenklaus,Siegfried Weiss,Carlos A. Guzmán +5 more
TL;DR: It is shown that c-di-AMP induces the cell surface up-regulation of T cell co-stimulatory molecules as well as the production of interferon-β in dendritic cells and macrophages following mucosal administration.
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An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection
Jason D. McArthur,Nicholas P. West,Jason N. Cole,Heidrun Jungnitz,Carlos A. Guzmán,James Chin,Philip R. Lehrbach,Steven P. Djordjevic,Mark J. Walker +8 more
TL;DR: An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica, harbouring mutations in aroA and trpE to investigate the use of such a strain as a live-attenuated vaccine, showed significantly reduced abilities to invade and survive within the mouse macrophage-like cell line J774A.
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The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and Qualitative Enhanced Immune Responses Post Immunization
TL;DR: It is demonstrated that bis-(3′,5′)-cyclic dimeric adenosine monophosphate (c-di-AMP) constitutes a promising adjuvant candidate stimulating both effective Th1/Th2 and cytotoxic immune responses when included in mucosal or parenteral vaccine formulations.