Carlos A. Guzmán

TL;DR: Analysis of the anti‐Tat IgG isotypes in serum, and the cytokine profile of spleen cells indicated that a dominant Th1 helper response was stimulated by Tat plus MALP‐2, as opposed to the Th2 response observed with Tat plus incomplete Freund's adjuvant, suggesting that Malp‐2 may represent an optimal mucosal adjUvant for candidate HIV vaccines based on Tat alone or in combination with other HIV antigens.

TL;DR: Results suggest that bvg-independent or bVG-downregulated products are involved in the uptake and intracellular survival of Bordetella bronchiseptica and may be relevant to natural infections caused by this organism that lead to chronicity or an altered immune response.

TL;DR: The adjuvanticity of MALP‐2 can be mediated, at least in part, by the stimulation of DC maturation, which in turn leads to an improved antigen presentation and is a promising molecule for the development of immune therapeutic or prophylactic interventions.

TL;DR: Intensive injections with E. coli TOP10 can induce clearance of CT26 tumors in BALB/c mice and re‐challenging mice which had cleared tumors showed that clearance was due to a specific immune reaction, paving the way for further optimization steps of this promising therapy.

TL;DR: These findings indicate that high titers of virus antigens reduce the efficacy of therapeutic vaccination, and anti-HBV siRNAs and therapeutic vaccines together might cure chronic HBV infection.