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Carlos A. Guzmán
Researcher at University of Genoa
Publications - 281
Citations - 10481
Carlos A. Guzmán is an academic researcher from University of Genoa. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 54, co-authored 260 publications receiving 9506 citations. Previous affiliations of Carlos A. Guzmán include Hannover Medical School & Bill & Melinda Gates Foundation.
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Journal ArticleDOI
Seropositivity for pathogens associated with chronic infections is a risk factor for all-cause mortality in the elderly: findings from the Memory and Morbidity in Augsburg Elderly (MEMO) Study
Marius Zeeb,Tobias Kerrinnes,Luka Cicin-Sain,Carlos A. Guzmán,Wolfram Puppe,Thomas F. Schulz,Annette Peters,Klaus Berger,Stefanie Castell,André Karch +9 more
TL;DR: An effect of seropositivity for Helicobacter pylori, cytomegalovirus, and Borrelia burgdorferi sensu lato on all-cause mortality in older community dwelling individuals is suggested.
Journal ArticleDOI
Rational Design of Vaccination Strategies to Promote Antigen Entry into the MHC Class I-Restricted Presentation Pathway
Pablo D. Becker,Carlos A. Guzmán +1 more
TL;DR: Current knowledge on the mechanisms used by professional APCs in the processing and presentation of endogenous and exogenous antigens in the context of MHC class I molecules are summarized (i.e. priming and cross-priming).
Journal ArticleDOI
Efficient phagocytosis of Klebsiella pneumoniae strains that poorly bind to human polymorphonuclear leukocytes.
Carla Pruzzo,Carlos A. Guzmán +1 more
TL;DR: It is suggested that PMN can phagocytize unopsonized bacteria through two different mechanisms, by one mechanism, observed with the fimbriated E. coli strain, PMN bind many more bacteria than those they can internalize, and by the other, observation with PSK strains, PMn bind only the bacteria they can immediately internalize.
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Cohort Profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood.
Cornelia Gottschick,Heike Raupach-Rosin,Susan Langer,Lamiaa Hassan,Johannes Horn,Evelyn Dorendorf,Mahrrouz Caputo,Martina Bittner,Lea Beier,Nicole Rübsamen,Kristin Maria Schlinkmann,Beate Zoch,Carlos A. Guzmán,Gesine Hansen,Valerie Heselich,Eva Holzapfel,Johannes Hübner,Thomas Pietschmann,Dietmar H. Pieper,Mathias W. Pletz,Peggy Riese,Andrea Schmidt-Pokrzywniak,Saskia Hartwig,Constantin von Kaisenberg,Mustafa Aydogdu,Matthias Buhles,Frank Dressler,Wolfgang Eberl,Roland Haase,Franz Koch,Susanne Feidicker,Torsten Frambach,Heiko G B Franz,Florian Guthmann,Hans G Koch,Sven Seeger,Carsten Oberhoff,Wladimir Pauker,Karl U. Petry,Ralf L. Schild,Michael Tchirikov,Eckhard Röhrig,André Karch,Rafael T. Mikolajczyk +43 more
Journal ArticleDOI
Optimizing rational vaccine design.
TL;DR: Considering the present state of the art, a subunit vaccine will probably be the strategy of choice, as the replacement of whole cell vaccines or semi‐crude antigen preparations by well‐defined antigens has dramatically improved their safety profile.