C
Carlos A. Guzmán
Researcher at University of Genoa
Publications - 281
Citations - 10481
Carlos A. Guzmán is an academic researcher from University of Genoa. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 54, co-authored 260 publications receiving 9506 citations. Previous affiliations of Carlos A. Guzmán include Hannover Medical School & Bill & Melinda Gates Foundation.
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Journal Article
Corrigendum to The member of the cyclic di-nucleotide family bis-(3',5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant
Rimma Libanova,Thomas Ebensen,Kai Schulze,Daniela Bruhn,Miriam Nörder,Tetyana Yevsa,Michael Morr,Carlos A. Guzmán +7 more
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Invariant NKT cell-mediated modulation of ILC1s as a tool for mucosal immune intervention
Stephanie Trittel,Neha Vashist,Thomas Ebensen,Benedict J. Chambers,Carlos A. Guzmán,Peggy Riese +5 more
TL;DR: The findings that ILC1s can become modulated by mucosally activated iNKT cells in a beneficial manner emphasize their up to now underestimated potential and renders them to be considered as targets for novel immune interventions.
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Self-reported diabetes and herpes zoster are associated with a weak humoral response to the seasonal influenza A H1N1 vaccine antigen among the elderly.
Manas K. Akmatov,Peggy Riese,Stephanie Trittel,Marcus May,Jana Prokein,Thomas Illig,Christoph Schindler,Carlos A. Guzmán,Frank Pessler +8 more
TL;DR: Diabetes and herpes zoster were identified as potentially modifiable risk factors for a poor vaccine response against influenza A antigens, but the results also reveal the need for broader investigations to identifyrisk factors for inadequate responses to influenza B antigen.
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HIV-1 matrix protein p17 modulates in vivo preactivated murine T-cell response and enhances the induction of systemic and mucosal immunity against intranasally co-administered antigens.
Simona Fiorentini,Pablo D. Becker,Elena Marini,Peggy Marconi,Manuela Avolio,Giorgio Tosti,Claudia Link,Roberto Manservigi,Carlos A. Guzmán,Arnaldo Caruso +9 more
TL;DR: The role of p17 in sustaining cellular activation and inflammation, thereby promoting a permissive microenvironment for HIV-1 replication is highlighted, and p17 is a promising candidate antigen, exhibiting immunomodulatory/adjuvant properties, that need to be exploited in the development of HIV/AIDS vaccines.
Journal ArticleDOI
Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population.
Manas K. Akmatov,Peggy Riese,Marcus May,Leonhard Jentsch,Malik W. Ahmed,Damaris Werner,Anja Rösel,Megan Tyler,Kevin Pessler,Jana Prokein,Inga Bernemann,Norman Klopp,Blair Prochnow,Stephanie Trittel,Aravind Tallam,Thomas Illig,Christoph Schindler,Carlos A. Guzmán,Frank Pessler +18 more
TL;DR: The low response rates indicate the need for optimized recruitment strategies if the study population is to be representative of the general population, and the complex prospective study design proved to be highly feasible.