C
Carolina Cruciani
Researcher at University of Zurich
Publications - 10
Citations - 513
Carolina Cruciani is an academic researcher from University of Zurich. The author has contributed to research in topics: Multiple sclerosis & Internal medicine. The author has an hindex of 5, co-authored 7 publications receiving 247 citations. Previous affiliations of Carolina Cruciani include University of Verona & Imperial College London.
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Journal ArticleDOI
Inflammatory intrathecal profiles and cortical damage in multiple sclerosis
Roberta Magliozzi,Roberta Magliozzi,Owain W. Howell,Richard Nicholas,Carolina Cruciani,Carolina Cruciani,Marco Castellaro,Chiara Romualdi,Stefania Rossi,Marco Pitteri,Maria Donata Benedetti,Alberto Gajofatto,Francesca B. Pizzini,Stefania Montemezzi,Sarah Rasia,Ruggero Capra,Alessandra Bertoldo,Francesco Facchiano,Salvatore Monaco,Richard Reynolds,Massimiliano Calabrese +20 more
TL;DR: Gray matter damage and meningeal inflammation have been associated with early disease onset and a more aggressive disease course in multiple sclerosis, but can these changes be identified in the patient early in the disease course?
Journal ArticleDOI
HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis
Jian Wang,Ivan Jelcic,Lena Mühlenbruch,Veronika Haunerdinger,Nora C. Toussaint,Nora C. Toussaint,Yingdong Zhao,Carolina Cruciani,Wolfgang Faigle,Reza Naghavian,Magdalena Foege,Thomas M.C. Binder,Thomas Eiermann,Lennart Opitz,Laura Fuentes-Font,Richard Reynolds,William W. Kwok,Julie T. Nguyen,Jar-How Lee,Andreas Lutterotti,Christian Münz,Hans-Georg Rammensee,Mathias Hauri-Hohl,Mireia Sospedra,Stefan Stevanovic,Roland Martin +25 more
TL;DR: Both HLA-DR15 allomorphs jointly shape an autore active T cell repertoire by serving as antigen-presenting structures and epitope sources and by presenting the same foreign peptides and autoantigens to autoreactive CD4+ T cells in MS.
Journal ArticleDOI
Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis.
Roberta Magliozzi,Roberta Magliozzi,Owain W. Howell,Owain W. Howell,Pascal F. Durrenberger,Eleonora Aricò,Rachel James,Carolina Cruciani,Cheryl Reeves,Federico Roncaroli,Richard Nicholas,Richard Reynolds +11 more
TL;DR: The inflammatory milieu generated in the subarachnoid space of the multiple sclerosis meninges by infiltrating immune cells leads to increased demyelinating and neurodegenerative pathology in the underlying grey matter due to changes in the balance of TNF signalling.
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GDP-l-fucose synthase is a CD4+ T cell–specific autoantigen in DRB3*02:02 patients with multiple sclerosis
Raquel Planas,Radleigh G. Santos,Paula Tomas-Ojer,Carolina Cruciani,Andreas Lutterotti,Wolfgang Faigle,Nicole Schaeren-Wiemers,Carmen Espejo,Herena Eixarch,Clemencia Pinilla,Roland Martin,Mireia Sospedra +11 more
TL;DR: GDP-l-fucose synthase is an autoantigen recognized by cerebrospinal fluid–infiltrating CD4+ T cells from HLA-DRB3*–positive patients with multiple sclerosis, and the possible role of this antigen as an inducer or driver of pathogenic autoimmune responses in multiple sclerosis is suggested.
Journal ArticleDOI
Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis.
Wolfgang Faigle,Carolina Cruciani,Witold Wolski,Bernd Roschitzki,Marco Puthenparampil,Paula Tomas-Ojer,Carla Sellés-Moreno,Thomas Zeis,Ivan Jelcic,Nicole Schaeren-Wiemers,Mireia Sospedra,Roland Martin +11 more
TL;DR: It is concluded that citrullination does not appear to be an important activating factor of a T cell response, but could be the consequence of an immune- or inflammatory response.