Catherine Legault

TL;DR: An autosomal-recessive Caspase Recruitment Domain-containing protein 9 (CARD9) deficiency in a patient with relapsing C. albicans meningoencephalitis is demonstrated and a novel, hypomorphic mutation with intact Th17 responses, but impaired GM-CSF responses is identified.

TL;DR: In this article, the authors describe the clinical characteristics and outcome of patients with cerebral venous sinus thrombosis (CVST) after SARS-CoV-2 vaccination with and without TTS.

TL;DR: The findings establish the CARD9/RASGRF1/ERK/GM-CSF axis as critical to the pathophysiology of sCNSc and demonstrate a consistent cellular phenotype of impaired GM- CSF responses.

TL;DR: Treatment recommendations for VITT comprised immunomodulation, non‐heparin anticoagulants, and avoidance of platelet transfusion and its association with mortality was evaluated.