C
Chantal Samson
Researcher at Pasteur Institute
Publications - 17
Citations - 2345
Chantal Samson is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Childhood obesity & Population. The author has an hindex of 15, co-authored 17 publications receiving 2286 citations. Previous affiliations of Chantal Samson include Centre national de la recherche scientifique & Laval University.
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Journal ArticleDOI
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
Sean V. Tavtigian,Jacques Simard,Johanna M. Rommens,Fergus J. Couch,Donna M Shattuck-Eidens,Susan L. Neuhausen,Sofia D. Merajver,Steinunn Thorlacius,Kenneth Offit,Dominique Stoppa-Lyonnet,Carole Bélanger,Russell Bell,Simin Berry,Robert Bogden,Qian Chen,Thaylon Davis,Martine Dumont,Cheryl Frye,T. Hattier,Srikanth Jammulapati,Teresa Janecki,Ping Jiang,Robert Kehrer,J.-F. Leblanc,J.T. Mitchell,Jodi Mcarthur-Morrison,K. Nguyen,Yi Peng,Chantal Samson,Marianne Schroeder,S.C. Snyder,Linda Steele,M. Stringfellow,C. Stroup,Bradley D. Swedlund,J. Swense,David H. F. Teng,Alun Thomas,T.D. Tran,Martine Tranchant,Jane Weaver-Feldhaus,Alexander K. C. Wong,Hiroaki Shizuya,Jorunn E. Eyfjord,Lisa A. Cannon-Albright,Fernand Labrie,Mark H. Skolnick,Mark H. Skolnick,Barbara L. Weber,Alexander Kamb,David E. Goldgar,David E. Goldgar +51 more
TL;DR: The complete coding sequence and exonic structure of BRCA2 is determined, and its pattern of expression is examined, and a mutational analysis of B RCA2 in families selected on the basis of linkage analysis and/or the presence of one or more cases of male breast cancer is reported.
Journal ArticleDOI
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
David Meyre,David Meyre,Nabila Bouatia-Naji,Agnès Tounian,Chantal Samson,Cecile Lecoeur,Cecile Lecoeur,Vincent Vatin,Maya Ghoussaini,Christophe Wachter,Serge Hercberg,Guillaume Charpentier,Wolfgang Patsch,François Pattou,Marie-Aline Charles,Patrick Tounian,Karine Clément,Béatrice Jouret,Jacques Weill,Betty A. Maddux,Ira D. Goldfine,Andrew Walley,Philippe Boutin,Christian Dina,Philippe Froguel,Philippe Froguel +25 more
TL;DR: Findings suggest that several variants of ENPP1 have a primary role in mediating insulin resistance and in the development of both obesity and T2D, suggesting that an underlying molecular mechanism is common to both conditions.
Journal ArticleDOI
Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families
Jacques Simard,Patricia N. Tonin,Francine Durocher,Kenneth Morgan,Johanna M. Rommens,Sebastien Gingras,Chantal Samson,J.-F. Leblanc,Carole Bélanger,F. Dion,Qingyun Liu,Mark H. Skolnick,Mark H. Skolnick,David E. Goldgar,Donna M Shattuck-Eidens,Fernand Labrie,Steven A. Narod +16 more
TL;DR: This article identified BRCA1 mutations in 12 of 30 (40%) Canadian families with breast and/or ovarian cancer, including six of the eight families (75%) that contained two cases of early-onset breast cancer.
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Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
Stéphane Cauchi,David Meyre,Christian Dina,Hélène Choquet,Chantal Samson,Sophie Gallina,Beverley Balkau,Guillaume Charpentier,François Pattou,Volodymyr Stetsyuk,Raphael Scharfmann,Bart Staels,Gema Frühbeck,Philippe Froguel +13 more
TL;DR: Evidence is provided that TCF7L2 is a major determinant of type 2 diabetes risk in European populations and suggests that this transcription factor plays a key role in glucose homeostasis.
Journal ArticleDOI
Comment on "A common genetic variant is associated with adult and childhood obesity".
Christian Dina,David Meyre,Chantal Samson,Jean Tichet,Michel Marre,Béatrice Jouret,Marie-Aline Charles,Marie-Aline Charles,Beverley Balkau,Beverley Balkau,Philippe Froguel,Philippe Froguel +11 more
TL;DR: This work attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.