F
Fergus J. Couch
Researcher at Laval University
Publications - 55
Citations - 6681
Fergus J. Couch is an academic researcher from Laval University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 25, co-authored 55 publications receiving 6382 citations. Previous affiliations of Fergus J. Couch include Howard Hughes Medical Institute & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
Sean V. Tavtigian,Jacques Simard,Johanna M. Rommens,Fergus J. Couch,Donna M Shattuck-Eidens,Susan L. Neuhausen,Sofia D. Merajver,Steinunn Thorlacius,Kenneth Offit,Dominique Stoppa-Lyonnet,Carole Bélanger,Russell Bell,Simin Berry,Robert Bogden,Qian Chen,Thaylon Davis,Martine Dumont,Cheryl Frye,T. Hattier,Srikanth Jammulapati,Teresa Janecki,Ping Jiang,Robert Kehrer,J.-F. Leblanc,J.T. Mitchell,Jodi Mcarthur-Morrison,K. Nguyen,Yi Peng,Chantal Samson,Marianne Schroeder,S.C. Snyder,Linda Steele,M. Stringfellow,C. Stroup,Bradley D. Swedlund,J. Swense,David H. F. Teng,Alun Thomas,T.D. Tran,Martine Tranchant,Jane Weaver-Feldhaus,Alexander K. C. Wong,Hiroaki Shizuya,Jorunn E. Eyfjord,Lisa A. Cannon-Albright,Fernand Labrie,Mark H. Skolnick,Mark H. Skolnick,Barbara L. Weber,Alexander Kamb,David E. Goldgar,David E. Goldgar +51 more
TL;DR: The complete coding sequence and exonic structure of BRCA2 is determined, and its pattern of expression is examined, and a mutational analysis of B RCA2 in families selected on the basis of linkage analysis and/or the presence of one or more cases of male breast cancer is reported.
Journal ArticleDOI
Pharmacogenetics of Tamoxifen Biotransformation Is Associated With Clinical Outcomes of Efficacy and Hot Flashes
Matthew P. Goetz,James M. Rae,Vera J. Suman,Stephanie L. Safgren,Matthew M. Ames,Daniel W. Visscher,Carol Reynolds,Fergus J. Couch,Wilma L. Lingle,David A. Flockhart,Zeruesenay Desta,Edith A. Perez,James N. Ingle +12 more
TL;DR: In tamoxifen-treated patients, women with the CYP2D6 *4/*4 genotype tend to have a higher risk of disease relapse and a lower incidence of hot flashes, which is consistent with the previous observation that CYP3A5*3 variant was not associated with any of these clinical outcomes.
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Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk
Douglas F. Easton,Paul D.P. Pharoah,Antonis C. Antoniou,Marc Tischkowitz,Sean V. Tavtigian,Katherine L. Nathanson,Peter Devilee,Alfons Meindl,Fergus J. Couch,Melissa C. Southey,David E. Goldgar,D. Gareth Evans,Georgia Chenevix-Trench,Nurul Hidayah Ab Rahman,Mark E. Robson,Susan M. Domchek,William D. Foulkes +16 more
TL;DR: An international group of cancer geneticists review the level of evidence for the association of gene variants with the risk of breast cancer and it is difficult to draw firm conclusions from the data because of ascertainment bias and the lack of data from large populations.
Journal ArticleDOI
BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer.
Fergus J. Couch,Michelle L. Deshano,M.A. Blackwood,Kathleen A. Calzone,Jill Stopfer,Campeau L,Ganguly A,Timothy R. Rebbeck,Barbara L. Weber +8 more
TL;DR: The results suggest that even in a referral clinic specializing in screening women from high-risk families, the majority of tests for BRCA1 mutations will be negative and therefore uninformative.
Journal ArticleDOI
A Collaborative Survey of 80 Mutations in the BRCA1 Breast and Ovarian Cancer Susceptibility Gene: Implications for Presymptomatic Testing and Screening
Donna Shattuck Eidens,Melody Mcclure,Jacques Simard,Fernand Labrie,Steve Narod,Fergus J. Couch,Kent Hoskins,Barbara L. Weber,Lucio H. Castilla,Mike Erdos,Lawrence C. Brody,Lori Friedman,Elizabeth A. Ostermeyer,Csilla Szabo,Mary-Claire King,Suresh C. Jhanwar,Kenneth Offit,Larry Norton,Teresa Gilewski,Mathew Lubin,Michael P. Osborne,Donald W. Black,Marie Boyd,Michael Steel,Sue A. Ingles,Robert W. Haile,Annika Lindblom,Håkan Olsson,Åke Borg,D. Timothy Bishop,Ellen Solomon,Paolo Radice,Giovanbattista Spatti,Simon A. Gayther,Bruce A.J. Ponder,William H. Warren,Michael R. Stratton,Qingyun Liu,Frank Fujimura,Cathryn M. Lewis,Mark H. Skolnick,David E. Goldgar +41 more
TL;DR: The high frequency of protein-terminating mutations and the observation of many recurrent mutations found in a diverse set of samples could lead to a relatively simple diagnostic test for BRCA1 mutations.