W
Wah Heng Lee
Researcher at Genome Institute of Singapore
Publications - 18
Citations - 2923
Wah Heng Lee is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: Human genome & Genome. The author has an hindex of 12, co-authored 18 publications receiving 2580 citations. Previous affiliations of Wah Heng Lee include Agency for Science, Technology and Research & National University of Singapore.
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Journal ArticleDOI
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
Wing-Kin Sung,Hancheng Zheng,Shuyu Li,Ronghua Chen,Xiao Liu,Yingrui Li,Nikki P. Lee,Wah Heng Lee,Pramila N. Ariyaratne,Chandana Tennakoon,Fabianus Hendriyan Mulawadi,Kwong F. Wong,Angela M. Liu,Ronnie T.P. Poon,Sheung Tat Fan,KL Chan,Zhuolin Gong,Yujie Hu,Zhao Lin,Guan Wang,Qinghui Zhang,Thomas D. Barber,Wen-Chi Chou,Amit Aggarwal,Ke Hao,Wei Zhou,Chunsheng Zhang,James S. Hardwick,James S. Hardwick,Carolyn A. Buser,Jiangchun Xu,Zhengyan Kan,Hongyue Dai,Mao Mao,Mao Mao,Christoph Reinhard,Jun Wang,Jun Wang,John M. Luk +38 more
TL;DR: Evidence is reported that suggests that the number of HBV integrations is associated with patient survival and copy-number variations were significantly increased at HBV breakpoint locations where chromosomal instability was likely induced.
Journal ArticleDOI
RNA Viral Community in Human Feces: Prevalence of Plant Pathogenic Viruses
Tao Zhang,Mya Breitbart,Wah Heng Lee,Jin-Quan Run,Chia-Lin Wei,Shirlena Wee Ling Soh,Martin L. Hibberd,Edison T. Liu,Forest Rohwer,Yijun Ruan +9 more
TL;DR: The most abundant fecal virus in this study was pepper mild mottle virus (PMMV), which was found in high concentrations—up to 109 virions per gram of dry weight fecal matter, indicating that this plant virus is prevalent in the human population.
Journal ArticleDOI
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.
King Pan Ng,Axel M. Hillmer,Charles Chuah,Charles Chuah,Wen Chun Juan,Tun Kiat Ko,Audrey S.M. Teo,Pramila N. Ariyaratne,Naoto Takahashi,Kenichi Sawada,Yao Fei,Yao Fei,Sheila Soh,Wah Heng Lee,John W.J. Huang,John Carson Allen,Xing Yi Woo,Niranjan Nagarajan,Vikrant Kumar,Anbupalam Thalamuthu,Wan Ting Poh,Ai Leen Ang,Hae Tha Mya,Gee Fung How,L.Y. Yang,Liang Piu Koh,Balram Chowbay,Chia-Tien Chang,V. S. Nadarajan,Wee Joo Chng,Hein Than,Lay Cheng Lim,Yeow Tee Goh,Shenli Zhang,Dianne Poh,Patrick Tan,Patrick Tan,Ju Ee Seet,Mei-Kim Ang,Noan-Minh Chau,Quan Sing Ng,Daniel Shao-Weng Tan,Manabu Soda,Kazutoshi Isobe,Markus M. Nöthen,Tien Yin Wong,Atif Shahab,Xiaoan Ruan,Valere Cacheux-Rataboul,Wing-Kin Sung,Eng Huat Tan,Yasushi Yatabe,Hiroyuki Mano,Hiroyuki Mano,Ross A. Soo,Tan Min Chin,Wan-Teck Lim,Yijun Ruan,Yijun Ruan,S. Tiong Ong +59 more
TL;DR: The results offer an explanation for the heterogeneity of TKI responses across individuals and suggest the possibility of personalizing therapy with BH3 mimetics to overcome BIM-polymorphism–associated TKI resistance.
Journal ArticleDOI
The Airborne Metagenome in an Indoor Urban Environment
Susannah G. Tringe,Susannah G. Tringe,Tao Zhang,Xuguo Liu,Yiting Yu,Wah Heng Lee,Jennifer Yap,Fei Yao,Sim Tiow Suan,Seah Keng Ing,Matthew Haynes,Forest Rohwer,Chia-Lin Wei,Patrick Tan,James Bristow,James Bristow,Edward M. Rubin,Edward M. Rubin,Yijun Ruan +18 more
TL;DR: A baseline index of air microbiota will be valuable for improving designs of surveillance for natural or man-made release of virulent pathogens.
Journal ArticleDOI
Mapping of transcription factor binding regions in mammalian cells by ChIP: Comparison of array- and sequencing-based technologies
Ghia Euskirchen,Joel Rozowsky,Chia-Lin Wei,Wah Heng Lee,Zhengdong D. Zhang,Stephen Hartman,Olof Emanuelsson,Viktor Stolc,Sherman M. Weissman,Mark Gerstein,Yijun Ruan,Michael Snyder +11 more
TL;DR: It is found that Chip-chip and ChIP-PET are frequently complementary in their relative abilities to detect STAT1 targets for the lower ranked targets; each method detected validated targets that were missed by the other method.