J
John Carson Allen
Researcher at National University of Singapore
Publications - 280
Citations - 6503
John Carson Allen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 32, co-authored 252 publications receiving 4970 citations. Previous affiliations of John Carson Allen include University of Wales & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.
King Pan Ng,Axel M. Hillmer,Charles Chuah,Charles Chuah,Wen Chun Juan,Tun Kiat Ko,Audrey S.M. Teo,Pramila N. Ariyaratne,Naoto Takahashi,Kenichi Sawada,Yao Fei,Yao Fei,Sheila Soh,Wah Heng Lee,John W.J. Huang,John Carson Allen,Xing Yi Woo,Niranjan Nagarajan,Vikrant Kumar,Anbupalam Thalamuthu,Wan Ting Poh,Ai Leen Ang,Hae Tha Mya,Gee Fung How,L.Y. Yang,Liang Piu Koh,Balram Chowbay,Chia-Tien Chang,V. S. Nadarajan,Wee Joo Chng,Hein Than,Lay Cheng Lim,Yeow Tee Goh,Shenli Zhang,Dianne Poh,Patrick Tan,Patrick Tan,Ju Ee Seet,Mei-Kim Ang,Noan-Minh Chau,Quan Sing Ng,Daniel Shao-Weng Tan,Manabu Soda,Kazutoshi Isobe,Markus M. Nöthen,Tien Yin Wong,Atif Shahab,Xiaoan Ruan,Valere Cacheux-Rataboul,Wing-Kin Sung,Eng Huat Tan,Yasushi Yatabe,Hiroyuki Mano,Hiroyuki Mano,Ross A. Soo,Tan Min Chin,Wan-Teck Lim,Yijun Ruan,Yijun Ruan,S. Tiong Ong +59 more
TL;DR: The results offer an explanation for the heterogeneity of TKI responses across individuals and suggest the possibility of personalizing therapy with BH3 mimetics to overcome BIM-polymorphism–associated TKI resistance.
Journal ArticleDOI
A switch from white to brown fat increases energy expenditure in cancer-associated cachexia.
Michele Petruzzelli,Martina Schweiger,Renate Schreiber,Ramon Campos-Olivas,Maria Tsoli,John Carson Allen,Michael M. Swarbrick,Stefan Rose-John,Mercedes Rincon,Graham R. Robertson,Rudolf Zechner,Erwin F. Wagner +11 more
TL;DR: Inhibition of WAT browning represents a promising approach to ameliorate cachexia in cancer patients and is shown to reduce the severity of cachexia.
Journal ArticleDOI
Microvascular invasion is a better predictor of tumor recurrence and overall survival following surgical resection for hepatocellular carcinoma compared to the Milan criteria.
Kheng-Choon Lim,Pierce K. H. Chow,John Carson Allen,Ghim-Song Chia,Miaoshan Lim,Peng-Chung Cheow,Alexander Y. F. Chung,London L.P.J. Ooi,Say Beng Tan +8 more
TL;DR: Assessment of McVI should aid in patient selection for adjuvant treatments to improve outcomes after SR and show that McVI is a better predictor of tumor recurrence and OS than the Milan criteria after SR for HCC.
Journal ArticleDOI
Performance of Delayed-Enhancement Magnetic Resonance Imaging With Gadoversetamide Contrast for the Detection and Assessment of Myocardial Infarction An International, Multicenter, Double-Blinded, Randomized Trial
Raymond J. Kim,Timothy S. E. Albert,James H. Wible,Michael D. Elliott,John Carson Allen,Jennifer C. Lee,Michele Parker,Alicia M. Napoli,Robert M. Judd +8 more
TL;DR: Gadoversetamide-enhanced MRI using doses of ≥0.2 mmol/kg is effective in the detection and assessment of both acute and chronic MI.
Journal ArticleDOI
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia
TL;DR: The women who received nimodipine were more likely to have a seizure than those who received magnesium sulfate, and the primary outcome measure was the development of eclampsia, as defined by a witnessed tonic–clonic seizure.