C
Chris A. Kaiser
Researcher at Massachusetts Institute of Technology
Publications - 68
Citations - 13092
Chris A. Kaiser is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Endoplasmic reticulum & Protein disulfide-isomerase. The author has an hindex of 50, co-authored 68 publications receiving 12554 citations. Previous affiliations of Chris A. Kaiser include Kettering University & University of California, Berkeley.
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Journal ArticleDOI
The genetic landscape of a cell.
Michael Costanzo,Anastasia Baryshnikova,Jeremy Bellay,Yungil Kim,Eric D. Spear,Carolyn S. Sevier,Huiming Ding,Judice L. Y. Koh,Kiana Toufighi,Sara Mostafavi,Jeany Prinz,Robert P. St.Onge,Benjamin VanderSluis,Taras Makhnevych,Franco J. Vizeacoumar,Solmaz Alizadeh,Sondra Bahr,Renee L. Brost,Yiqun Chen,Murat Cokol,Raamesh Deshpande,Zhijian Li,Zhen Yuan Lin,Wendy Liang,Michaela Marback,Jadine Paw,Bryan Joseph San Luis,Ermira Shuteriqi,Amy Hin Yan Tong,Nydia Van Dyk,Iain M. Wallace,Joseph Whitney,Matthew T. Weirauch,Guoqing Zhong,Hongwei Zhu,Walid A. Houry,Michael Brudno,Sasan Ragibizadeh,Balázs Papp,Csaba Pál,Frederick P. Roth,Guri Giaever,Corey Nislow,Olga G. Troyanskaya,Howard Bussey,Gary D. Bader,Anne-Claude Gingras,Quaid Morris,Philip M. Kim,Chris A. Kaiser,Chad L. Myers,Brenda J. Andrews,Charles Boone +52 more
TL;DR: A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function.
Journal ArticleDOI
Formation and transfer of disulphide bonds in living cells.
TL;DR: The recent identification of new redox-active proteins in humans and yeast that mechanistically parallel the more established redox -active enzymes indicates that there might be further uncharacterized redox pathways throughout the cell.
Journal ArticleDOI
Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway
Chris A. Kaiser,Randy Schekman +1 more
TL;DR: Mutations in two of the genes involved in vesicle fusion, SEC17 and SEC18, are lethal in combination, and five of six possible pairwise combinations of mutations in genes required for vesicles formation, SEC12, SEC13, SEC16, and SEC23, are fatal.
Journal ArticleDOI
Exploration of essential gene functions via titratable promoter alleles
Sanie Mnaimneh,Armaity P. Davierwala,Jennifer Haynes,Jason Moffat,Wen-Tao Peng,Wen Zhang,Xueqi Yang,Jeff Pootoolal,Gordon Chua,Andres Lopez,Miles Trochesset,Darcy L Morse,Nevan J. Krogan,Shawna L. Hiley,Zhijian Li,Quaid Morris,Jörg Grigull,Nicholas Mitsakakis,Christopher J. Roberts,Jack Greenblatt,Charles Boone,Chris A. Kaiser,Brenda J. Andrews,Timothy P. Hughes +23 more
TL;DR: This study created promoter-shutoff strains for over two-thirds of all essential yeast genes and subjected them to morphological analysis, size profiling, drug sensitivity screening, and microarray expression profiling, which identified genes involved in ribosome biogenesis, protein secretion, mitochondrial import, and tRNA charging.
Journal ArticleDOI
Nitrogen regulation in Saccharomyces cerevisiae.
Boris Magasanik,Chris A. Kaiser +1 more
TL;DR: The historical foundations of the study of nitrogen regulation as well as the current understanding of the regulatory networks that underlie nitrogen regulation are discussed.