C
Chris Parker
Researcher at Institute of Cancer Research
Publications - 479
Citations - 35757
Chris Parker is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Prostate cancer & Radiation therapy. The author has an hindex of 79, co-authored 422 publications receiving 30260 citations. Previous affiliations of Chris Parker include The Royal Marsden NHS Foundation Trust & University of Toronto.
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A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
Ali Amin Al Olama,Zsofia Kote-Jarai,Fredrick R. Schumacher,Fredrik Wiklund,Sonja I. Berndt,S. Benlloch,Graham G. Giles,Gianluca Severi,David E. Neal,Freddie C. Hamdy,Jenny L Donovan,David J. Hunter,B. E. Henderson,Michael J. Thun,Michael Gaziano,Edward Giovannucci,A. Siddiq,Ruth C. Travis,David G. Cox,Federico Canzian,Elio Riboli,Timothy J. Key,Gerald L. Andriole,Demetrius Albanes,Richard B. Hayes,Johanna Schleutker,Anssi Auvinen,Teuvo L.J. Tammela,Maren Weischer,Janet L. Stanford,Elaine A. Ostrander,Cezary Cybulski,Jan Lubinski,S. N. Thibodeau,D J Schaid,Karina Dalsgaard Sørensen,Jyotsna Batra,Judith A. Clements,Suzanne K. Chambers,Joanne F. Aitken,Robert A. Gardiner,Christiane Maier,W. Vogel,Thilo Dörk,Hermann Brenner,Tomonori Habuchi,Sue A. Ingles,Esther M. John,Joanne L. Dickinson,Lisa A. Cannon-Albright,Manuel R. Teixeira,Radka Kaneva,Hong Wei Zhang,Yong-Jie Lu,Jong Y. Park,Kathleen A. Cooney,Kenneth Muir,Daniel Leongamornlert,E. Saunders,Malgorzata Tymrakiewicz,N. Mahmud,Michelle Guy,K. Govindasami,Lynne T. O'Brien,R A Wilkinson,Amanda L. Hall,E J Sawyer,Tokhir Dadaev,Jonathan J. Morrison,David P. Dearnaley,Alan Horwich,Robert Huddart,Vincent Khoo,Chris Parker,N. van As,C.R.J. Woodhouse,Alan J. Thompson,Tim Dudderidge,Chris Ogden,Colin Cooper,Aritaya Lophatonanon,Melissa C. Southey,John L. Hopper,Dallas R. English,Jarmo Virtamo,Loic Le Marchand,D. Campa,Rudolph Kaaks,S. Lindstrom,W. R. Diver,Susan M. Gapstur,M. Yeager,Angela Cox,Mariana C. Stern,Roman Corral,M. Aly,W. Isaacs,Jan Adolfsson,Jianfeng Xu,Siqun L. Zheng,T. Wahlfors,Kimmo Taari,Paula Kujala,Peter Klarskov,Børge G. Nordestgaard,Roder,Ruth Frikke-Schmidt,S.E. Bojesen,Liesel M. FitzGerald,Suzanne Kolb,Erika M. Kwon,Danielle M. Karyadi,Torben F. Ørntoft,Michael Borre,Antje E. Rinckleb,Manuel Luedeke,Kathleen Herkommer,Andreas Meyer,Jürgen Serth,James R. Marthick,Briony Patterson,Dominika Wokołorczyk,Amanda B. Spurdle,Felicity Lose,Shannon K. McDonnell,Amit Joshi,Ahva Shahabi,Pedro Vaz Pinto,João Vasco Santos,Anna M. Ray,T A Sellers,Hui-Yi Lin,Robert A. Stephenson,Craig C. Teerlink,Müller H,Dietrich Rothenbacher,Norihiko Tsuchiya,Shintaro Narita,Guangwen Cao,C. Slavov,V. Mitev,S. J. Chanock,Henrik Grönberg,Christopher A. Haiman,Peter Kraft,Doug Easton,Rosalind A. Eeles +146 more
TL;DR: In this article, the authors conducted a meta-analysis of four GWAS including 5953 cases of aggressive prostate cancer and 11 463 controls (men without PrCa) and computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples through the international PRACTICAL and BPC3 consortia.
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Transatlantic Consensus Group on active surveillance and focal therapy for prostate cancer
Hashim U. Ahmed,Oguz Akin,Jonathan A. Coleman,Sarah Crane,Mark Emberton,Larry Goldenberg,Hedvig Hricak,M. W. Kattan,John Kurhanewicz,Caroline M. Moore,Chris Parker,Thomas J. Polascik,Peter T. Scardino,Nicholas van As,Arnauld Villers +14 more
TL;DR: The largest ever study of its kind has been conducted on the role of language and culture in the development of Alzheimer's disease and its effects on physical and mental health.
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Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study.
David Olmos,David Olmos,Daniel Brewer,Jeremy Clark,Daniel C. Danila,Chris Parker,Gerhardt Attard,Gerhardt Attard,Martin Fleisher,Alison Reid,Alison Reid,Elena Castro,Elena Castro,Shahneen Sandhu,Shahneen Sandhu,Lorraine Barwell,Nikhil Babu Oommen,Suzanne Carreira,Charles G. Drake,Robert Jones,Colin Cooper,Howard I. Scher,Johann S. de Bono,Johann S. de Bono +23 more
TL;DR: The results suggest that whole-blood gene profiling could identify gene-expression signatures that stratify patients with castration-resistant prostate cancer into distinct prognostic groups.
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Evaluation of circulating tumor cell (CTC) enumeration as an efficacy response biomarker of overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC): Planned final analysis (FA) of COU-AA-301, a randomized, double-blind, placebo-controlled, phase III study of abiraterone acetate (AA) plus low-dose prednisone (P) post docetaxel.
Howard I. Scher,G. Heller,Ana M. Molina,T. Kheoh,G. Attard,J. Moreira,Shahneen Sandhu,Chris Parker,Christopher J. Logothetis,Robert T. McCormack,Karim Fizazi,Aseem Anand,Daniel C. Danila,Martin Fleisher,David Olmos,C. M. Haqq,J.S. de Bono +16 more
TL;DR: Using standard definition of CTC conversion, the biomarker panel demonstrated a level of surrogacy for OS by correlating well with survival and in a model-adjusted analysis dramatically attenuating the treatment effect.
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Androgen withdrawal in patients reduces prostate cancer hypoxia : Implications for disease progression and radiation response
Michael Milosevic,Michael Milosevic,Peter Chung,Chris Parker,Robert G. Bristow,Ants Toi,Tony Panzarella,Padraig Warde,Charles Catton,Cynthia Ménard,Andrew Bayley,Mary Gospodarowicz,Richard P. Hill +12 more
TL;DR: Results might explain the improved patient outcome that has been observed in clinical trials of radiotherapy and hormones, and suggest a role for novel therapeutic agents that block the molecular response to hypoxia in prostate cancer either alone or in combination with other established treatments.