T
T. Wahlfors
Researcher at University of Turku
Publications - 6
Citations - 675
T. Wahlfors is an academic researcher from University of Turku. The author has contributed to research in topics: Genome-wide association study & Prostate cancer. The author has an hindex of 5, co-authored 6 publications receiving 626 citations.
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Journal ArticleDOI
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
Zsofia Kote-Jarai,Olama Aaa.,G.G. Giles,G.G. Giles,Gianluca Severi,Gianluca Severi,Johanna Schleutker,Maren Weischer,Daniele Campa,Elio Riboli,Timothy J. Key,Henrik Grönberg,David J. Hunter,Peter Kraft,Michael J. Thun,Sue A. Ingles,Stephen J. Chanock,Stephen J. Chanock,Demetrius Albanes,Richard B. Hayes,David E. Neal,David E. Neal,Freddie C. Hamdy,Jenny L Donovan,Paul D.P. Pharoah,Fredrick R. Schumacher,Brian E. Henderson,Janet L. Stanford,Janet L. Stanford,Elaine A. Ostrander,Karina Dalsgaard Sørensen,Thilo Dörk,Gerald L. Andriole,Joanne L. Dickinson,Cezary Cybulski,Jan Lubinski,Amanda B. Spurdle,Judith A. Clements,Suzanne K. Chambers,Joanne F. Aitken,Gardiner Raf.,S. N. Thibodeau,D J Schaid,Esther M. John,Esther M. John,Christiane Maier,W. Vogel,Kathleen A. Cooney,Jong Y. Park,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hermann Brenner,Tomonori Habuchi,Zhang H-W.,Lu Y-J.,Radka Kaneva,Kenneth Muir,Sara Benlloch,Daniel Leongamornlert,Ed Saunders,Malgorzata Tymrakiewicz,N. Mahmud,Michelle Guy,Lynne T. O'Brien,R A Wilkinson,Amanda L. Hall,E J Sawyer,Tokhir Dadaev,Jonathan J. Morrison,David P. Dearnaley,David P. Dearnaley,Alan Horwich,Alan Horwich,Robert Huddart,Robert Huddart,Vincent Khoo,Vincent Khoo,Chris Parker,Chris Parker,N. van As,C.R.J. Woodhouse,A. Thompson,Timothy J. Christmas,Chris Ogden,Colin Cooper,Aritaya Lophatonanon,Melissa C. Southey,John L. Hopper,Dallas R. English,Dallas R. English,T. Wahlfors,Tammela Tlj.,Peter Klarskov,Børge G. Nordestgaard,Martin Andreas Røder,Anne Tybjærg-Hansen,Stig E. Bojesen,Ruth C. Travis,Federico Canzian,Rudolph Kaaks,Fredrik Wiklund,Markus Aly,Sara Lindström,W. R. Diver,Susan M. Gapstur,Mariana C. Stern,Roman Corral,Jarmo Virtamo,Angela Cox,Christopher A. Haiman,Loic Le Marchand,Liesel M. FitzGerald,Suzanne Kolb,Erika M. Kwon,Danielle M. Karyadi,Torben F. Ørntoft,Michael Borre,Andreas Meyer,Jürgen Serth,Meredith Yeager,Sonja I. Berndt,James R. Marthick,Briony Patterson,Dominika Wokołorczyk,Jyotsna Batra,Felicity Lose,Shannon K. McDonnell,Amit Joshi,A Shahabi,Antje E. Rinckleb,A Ray,T A Sellers,Lin H-Y.,Robert A. Stephenson,J. M. Farnham,Heiko Müller,Dietrich Rothenbacher,Norihiko Tsuchiya,Shintaro Narita,Cao G-W.,C. Slavov,Vanio Mitev,Douglas F. Easton,Rosalind A. Eeles,Rosalind A. Eeles +144 more
TL;DR: The results of stage 3 are reported, in which 1,536 SNPs are evaluated in 4,574 individuals with prostate cancer (cases) and 4,164 controls and a SNP in TERT more strongly associated with PrCa than that previously reported is identified.
Journal ArticleDOI
Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.
Siddhartha Kar,Jonathan Beesley,Ali Amin Al Olama,Kyriaki Michailidou,Jonathan Tyrer,Zsofia Kote-Jarai,Kate Lawrenson,Sara Lindström,Susan J. Ramus,Deborah J. Thompson,Abctb Investigators,Adam S. Kibel,Agnieszka Dansonka-Mieszkowska,Agnieszka Michael,Aida Karina Dieffenbach,Aleksandra Gentry-Maharaj,Alice S. Whittemore,Alicja Wolk,Alvaro N.A. Monteiro,Ana Peixoto,Andrzej M. Kierzek,Angela Cox,Anja Rudolph,Anna González-Neira,Anna H. Wu,Annika Lindblom,Anthony J. Swerdlow,Apcb BioResource,Argyrios Ziogas,Arif B. Ekici,Barbara Burwinkel,Beth Y. Karlan,Børge G. Nordestgaard,Carl Blomqvist,Catherine M. Phelan,Catriona McLean,Celeste Leigh Pearce,Celine M. Vachon,Cezary Cybulski,C. Slavov,Christa Stegmaier,Christiane Maier,Christine B. Ambrosone,Claus Høgdall,Craig C. Teerlink,Daehee Kang,Daehee Kang,Daniel C. Tessier,Daniel J. Schaid,Daniel O. Stram,Daniel W. Cramer,David E. Neal,Diana Eccles,Dieter Flesch-Janys,Digna R. Velez Edwards,Dominika Wokozorczyk,Douglas A. Levine,Drakoulis Yannoukakos,Elinor J. Sawyer,Elisa V. Bandera,Elizabeth M. Poole,Elizabeth M. Poole,Ellen L. Goode,Elza Khusnutdinova,Elza Khusnutdinova,Estrid Høgdall,Fengju Song,Fiona Bruinsma,Florian Heitz,Francesmary Modugno,Freddie C. Hamdy,Freddie C. Hamdy,Fredrik Wiklund,Graham G. Giles,Graham G. Giles,Graham G. Giles,Håkan Olsson,Hans Wildiers,Hans-Ulrich Ulmer,Hardev Pandha,Harvey A. Risch,Hatef Darabi,Helga B. Salvesen,Helga B. Salvesen,Heli Nevanlinna,Henrik Grönberg,Hermann Brenner,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Hoda Anton-Culver,Honglin Song,Hui-Yi Lim,Iain A. McNeish,Ian G. Campbell,Ian G. Campbell,Ignace Vergote,Jacek Gronwald,Jan Lubinski,Janet L. Stanford,Janet L. Stanford,Javier Benitez,Jennifer A. Doherty,Jennifer B. Permuth,Jenny Chang-Claude,Jenny L Donovan,Joe Dennis,Joellen M. Schildkraut,Joellen M. Schildkraut,Johanna Schleutker,Johanna Schleutker,John L. Hopper,Jolanta Kupryjanczyk,Jong Y. Park,Jonine D. Figueroa,Judith A. Clements,Julia A. Knight,Julia A. Knight,Julian Peto,Julie M. Cunningham,Julio M. Pow-Sang,Jyotsna Batra,Kamila Czene,Karen Lu,Kathleen Herkommer,Kay-Tee Khaw,kConFab Investigators,Keitaro Matsuo,Kenneth Muir,Kenneth Muir,Kenneth Offitt,Kexin Chen,Kirsten B. Moysich,Kristiina Aittomäki,Kunle Odunsi,Lambertus A. Kiemeney,Leon F.A.G. Massuger,Liesel M. FitzGerald,Linda S. Cook,Lisa A. Cannon-Albright,Maartje J. Hooning,Malcolm C. Pike,Manjeet K. Bolla,Manuel Luedeke,Manuel R. Teixeira,Marc T. Goodman,Marjanka K. Schmidt,Marjorie J. Riggan,Markus Aly,Mary Anne Rossing,Mary Anne Rossing,Matthias W. Beckmann,Matthieu Moisse,Maureen Sanderson,Melissa C. Southey,Michael Jones,Michael Lush,Michelle A.T. Hildebrandt,Ming-Feng Hou,Minouk J. Schoemaker,Montserrat Garcia-Closas,Montserrat Garcia-Closas,Natalia Bogdanova,Nazneen Rahman,Nbcs Investigators,Nhu D. Le,Nick Orr,Nicolas Wentzensen,Nora Pashayan,Nora Pashayan,Paolo Peterlongo,Pascal Guénel,Paul Brennan,Paula Paulo,Penelope M. Webb,Per Broberg,Peter A. Fasching,Peter Devilee,Qin Wang,Qiuyin Cai,Qiyuan Li,Qiyuan Li,Radka Kaneva,Ralf Bützow,Reidun K. Kopperud,Reidun K. Kopperud,Rita K. Schmutzler,Robert A. Stephenson,Robert J. MacInnis,Robert J. MacInnis,Robert N. Hoover,Robert Winqvist,Roberta B. Ness,Roger L. Milne,Roger L. Milne,Ruth C. Travis,Sara Benlloch,Sara H. Olson,Shannon K. McDonnell,Shelley S. Tworoger,Shelley S. Tworoger,Sofia Maia,Sonja I. Berndt,Soo-Chin Lee,Soo-Chin Lee,Soo-Hwang Teo,Stephen N. Thibodeau,Stig E. Bojesen,Stig E. Bojesen,Susan M. Gapstur,Susanne K. Kjaer,Tanja Pejovic,Teuvo L.J. Tammela,Thilo Dörk,Thomas Brüning,T. Wahlfors,Timothy J. Key,Todd L. Edwards,Usha Menon,Ute Hamann,Vanio Mitev,Veli-Matti Kosma,Veronica Wendy Setiawan,Vessela N. Kristensen,Vessela N. Kristensen,Volker Arndt,Walther Vogel,Wei Zheng,Weiva Sieh,William J. Blot,Wojciech Kluzniak,Xiao-Ou Shu,Yu-Tang Gao,Fredrick R. Schumacher,Matthew L. Freedman,Matthew L. Freedman,Andrew Berchuck,Alison M. Dunning,Jacques Simard,Christopher A. Haiman,Amanda B. Spurdle,Thomas A. Sellers,David J. Hunter,Brian E. Henderson,Peter Kraft,Stephen J. Chanock,Fergus J. Couch,Per Hall,Simon A. Gayther,Douglas F. Easton,Georgia Chenevix-Trench,Rosalind A. Eeles,Rosalind A. Eeles,Paul D.P. Pharoah,Diether Lambrechts +254 more
TL;DR: In this article, a meta-analysis combining the largest genome-wide association data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10-8 seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loc
Journal ArticleDOI
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
Ali Amin Al Olama,Zsofia Kote-Jarai,Fredrick R. Schumacher,Fredrik Wiklund,Sonja I. Berndt,S. Benlloch,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,David E. Neal,David E. Neal,Freddie C. Hamdy,Jenny L Donovan,David J. Hunter,B. E. Henderson,Michael J. Thun,Michael Gaziano,Michael Gaziano,Edward Giovannucci,Afshan Siddiq,Ruth C. Travis,David G. Cox,David G. Cox,Federico Canzian,Elio Riboli,Timothy J. Key,Gerald L. Andriole,Demetrius Albanes,Richard B. Hayes,Johanna Schleutker,Johanna Schleutker,Anssi Auvinen,Tammela Tlj.,Maren Weischer,Janet L. Stanford,Janet L. Stanford,Elaine A. Ostrander,Cezary Cybulski,Jan Lubinski,S. N. Thibodeau,D J Schaid,Karina Dalsgaard Sørensen,Jyotsna Batra,Judith A. Clements,Suzanne K. Chambers,Suzanne K. Chambers,Joanne F. Aitken,Robert A. Gardiner,Christiane Maier,W. Vogel,Thilo Dörk,Hermann Brenner,Tomonori Habuchi,Sue A. Ingles,Esther M. John,Esther M. John,Joanne L. Dickinson,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Manuel R. Teixeira,Radka Kaneva,Zhang H-W.,Lu Y-J.,Jong Y. Park,Kathleen A. Cooney,Kenneth Muir,Daniel Leongamornlert,E. Saunders,Malgorzata Tymrakiewicz,N. Mahmud,Michelle Guy,K. Govindasami,Lynne T. O'Brien,R A Wilkinson,Amanda L. Hall,E J Sawyer,Tokhir Dadaev,Jonathan J. Morrison,David P. Dearnaley,Alan Horwich,Robert Huddart,Vincent Khoo,Chris Parker,N. van As,C.R.J. Woodhouse,A. Thompson,Tim Dudderidge,Chris Ogden,Colin Cooper,Aritaya Lophatonanon,Melissa C. Southey,John L. Hopper,Dallas R. English,Dallas R. English,Jarmo Virtamo,Loic Le Marchand,D Campa,Rudolph Kaaks,S. Lindstrom,W. R. Diver,Susan M. Gapstur,Meredith Yeager,Angela Cox,Mariana C. Stern,Roman Corral,Markus Aly,W. Isaacs,Jan Adolfsson,Jianfeng Xu,Siqun L. Zheng,T. Wahlfors,Kimmo Taari,Paula Kujala,Peter Klarskov,Børge G. Nordestgaard,Martin Andreas Røder,Ruth Frikke-Schmidt,Stig E. Bojesen,Liesel M. FitzGerald,Suzanne Kolb,Erika M. Kwon,Danielle M. Karyadi,Torben F. Ørntoft,Michael Borre,Antje E. Rinckleb,Manuel Luedeke,Kathleen Herkommer,Andreas Meyer,Jürgen Serth,James R. Marthick,Briony Patterson,Dominika Wokołorczyk,Amanda B. Spurdle,Felicity Lose,Shannon K. McDonnell,Amit Joshi,Ahva Shahabi,Pedro Vaz Pinto,João Vasco Santos,Anna M. Ray,T A Sellers,Lin H-Y.,Robert A. Stephenson,Craig C. Teerlink,Heiko Müller,Dietrich Rothenbacher,Norihiko Tsuchiya,Shintaro Narita,Cao G-W.,C. Slavov,Vanio Mitev,S. J. Chanock,Henrik Grönberg,Christopher A. Haiman,Peter Kraft,Doug Easton,Rosalind A. Eeles +157 more
TL;DR: In this article, the authors conducted a meta-analysis of four GWAS including 5953 cases of aggressive prostate cancer and 11 463 controls (men without PrCa) and computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples through the international PRACTICAL and BPC3 consortia.
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
Ali Amin Al Olama,Zsofia Kote-Jarai,Fredrick R. Schumacher,Fredrik Wiklund,Sonja I. Berndt,S. Benlloch,Graham G. Giles,Gianluca Severi,David E. Neal,Freddie C. Hamdy,Jenny L Donovan,David J. Hunter,B. E. Henderson,Michael J. Thun,Michael Gaziano,Edward Giovannucci,A. Siddiq,Ruth C. Travis,David G. Cox,Federico Canzian,Elio Riboli,Timothy J. Key,Gerald L. Andriole,Demetrius Albanes,Richard B. Hayes,Johanna Schleutker,Anssi Auvinen,Teuvo L.J. Tammela,Maren Weischer,Janet L. Stanford,Elaine A. Ostrander,Cezary Cybulski,Jan Lubinski,S. N. Thibodeau,D J Schaid,Karina Dalsgaard Sørensen,Jyotsna Batra,Judith A. Clements,Suzanne K. Chambers,Joanne F. Aitken,Robert A. Gardiner,Christiane Maier,W. Vogel,Thilo Dörk,Hermann Brenner,Tomonori Habuchi,Sue A. Ingles,Esther M. John,Joanne L. Dickinson,Lisa A. Cannon-Albright,Manuel R. Teixeira,Radka Kaneva,Hong Wei Zhang,Yong-Jie Lu,Jong Y. Park,Kathleen A. Cooney,Kenneth Muir,Daniel Leongamornlert,E. Saunders,Malgorzata Tymrakiewicz,N. Mahmud,Michelle Guy,K. Govindasami,Lynne T. O'Brien,R A Wilkinson,Amanda L. Hall,E J Sawyer,Tokhir Dadaev,Jonathan J. Morrison,David P. Dearnaley,Alan Horwich,Robert Huddart,Vincent Khoo,Chris Parker,N. van As,C.R.J. Woodhouse,Alan J. Thompson,Tim Dudderidge,Chris Ogden,Colin Cooper,Aritaya Lophatonanon,Melissa C. Southey,John L. Hopper,Dallas R. English,Jarmo Virtamo,Loic Le Marchand,D. Campa,Rudolph Kaaks,S. Lindstrom,W. R. Diver,Susan M. Gapstur,M. Yeager,Angela Cox,Mariana C. Stern,Roman Corral,M. Aly,W. Isaacs,Jan Adolfsson,Jianfeng Xu,Siqun L. Zheng,T. Wahlfors,Kimmo Taari,Paula Kujala,Peter Klarskov,Børge G. Nordestgaard,Roder,Ruth Frikke-Schmidt,S.E. Bojesen,Liesel M. FitzGerald,Suzanne Kolb,Erika M. Kwon,Danielle M. Karyadi,Torben F. Ørntoft,Michael Borre,Antje E. Rinckleb,Manuel Luedeke,Kathleen Herkommer,Andreas Meyer,Jürgen Serth,James R. Marthick,Briony Patterson,Dominika Wokołorczyk,Amanda B. Spurdle,Felicity Lose,Shannon K. McDonnell,Amit Joshi,Ahva Shahabi,Pedro Vaz Pinto,João Vasco Santos,Anna M. Ray,T A Sellers,Hui-Yi Lin,Robert A. Stephenson,Craig C. Teerlink,Müller H,Dietrich Rothenbacher,Norihiko Tsuchiya,Shintaro Narita,Guangwen Cao,C. Slavov,V. Mitev,S. J. Chanock,Henrik Grönberg,Christopher A. Haiman,Peter Kraft,Doug Easton,Rosalind A. Eeles +146 more
TL;DR: In this article, the authors conducted a meta-analysis of four GWAS including 5953 cases of aggressive prostate cancer and 11 463 controls (men without PrCa) and computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples through the international PRACTICAL and BPC3 consortia.
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
Alexander Gusev,Huwenbo Shi,Gleb Kichaev,Mark Pomerantz,Fugen Li,Henry W. Long,Sue A. Ingles,Rick A. Kittles,Sara S. Strom,Benjamin A. Rybicki,Barbara Nemesure,Williams B. Isaacs,Wei Zheng,Curtis A. Pettaway,E D Yeboah,Yao Tettey,Richard B. Biritwum,Alex A. Adjei,Evelyn Tay,Ann Truelove,Shelley Niwa,Anand P. Chokkalingam,Esther M. John,Adam B. Murphy,Lisa B. Signorello,John D. Carpten,M.C. Leske,Suh Yuh Wu,Anslem J.M. Hennis,Christine Neslund-Dudas,Ann W. Hsing,Lisa Chu,Phyllis J. Goodman,Eric A. Klein,John S. Witte,Graham Casey,Sam Kaggwa,Michael B. Cook,Daniel O. Stram,William J. Blot,Rosalind A. Eeles,Doug Easton,Zsofia Kote-Jarai,A A Al Olama,S. Benlloch,Kenneth Muir,Graham G. Giles,Melissa C. Southey,Liesel M. FitzGerald,Henrik Grönberg,Fredrik Wiklund,M. Aly,B. E. Henderson,Johanna Schleutker,T. Wahlfors,Teuvo L.J. Tammela,Børge G. Nordestgaard,Timothy J. Key,Ruth C. Travis,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Paul D.P. Pharoah,Nora Pashayan,Kay-Tee Khaw,Janet L. Stanford,S. N. Thibodeau,Shannon K. McDonnell,D J Schaid,Christiane Maier,W. Vogel,Manuel Luedeke,Kathleen Herkommer,Adam S. Kibel,Cezary Cybulski,Dominika Wokołorczyk,Wojciech Kluzniak,Lisa A. Cannon-Albright,Craig C. Teerlink,Hermann Brenner,A.K. Dieffenbach,Volker Arndt,Jong Y. Park,T A Sellers,Hui-Yi Lin,C. Slavov,Radka Kaneva,V. Mitev,Jyotsna Batra,Amanda B. Spurdle,Judith A. Clements,Manuel R. Teixeira,Hardev Pandha,Agnieszka Michael,Paula Paulo,Sofia Maia,Andrzej M. Kierzek,David V. Conti,Demetrius Albanes,Christine D. Berg,Sonja I. Berndt,D. Campa,E.D. Crawford,W. R. Diver,Susan M. Gapstur,John Michael Gaziano,Edward Giovannucci,Robert N. Hoover,David J. Hunter,Mattias Johansson,Peter Kraft,Loic Le Marchand,S. Lindstrom,C. Navarro,Kim Overvad,Elio Riboli,A. Siddiq,Victoria L. Stevens,D. Trichopoulos,Paolo Vineis,M. Yeager,Gosia Trynka,Soumya Raychaudhuri,Fredrick R. Schumacher,Alkes L. Price,Matthew L. Freedman,Christopher A. Haiman,Bogdan Pasaniuc +127 more
TL;DR: A genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa is built using genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue.