C
Christian Griesinger
Researcher at Max Planck Society
Publications - 449
Citations - 25595
Christian Griesinger is an academic researcher from Max Planck Society. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Residual dipolar coupling. The author has an hindex of 76, co-authored 408 publications receiving 23162 citations. Previous affiliations of Christian Griesinger include University of Göttingen & ETH Zurich.
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The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents.
Teresa Carlomagno,Marcel J. J. Blommers,Jens Meiler,Jens Meiler,Wolfgang Jahnke,Thomas Schupp,Frank Petersen,Dieter Schinzer,Karl-Heinz Altmann,Christian Griesinger +9 more
TL;DR: Mostofthedrugs available today for treatment of cancer are based on the inhibition ofcellproliferation and induction ofcelldeath by apoptosis, butinent subclass of compounds exert their cytotoxic activity by perturbing micro-tubuledynamics.
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A DMSO‐Compatible Orienting Medium: Towards the Investigation of the Stereochemistry of Natural Products
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A new approach for applying residual dipolar couplings as restraints in structure elucidation.
TL;DR: A protocol is proposed that translates dipolar couplings into intervector projection angles, which are independent of the orientation of the alignment tensor with respect to the molecule.
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Stereochemistry of sagittamide a from residual dipolar coupling enhanced NMR
Anne Schuetz,Jochen Junker,Andrei Leonov,Oliver F. Lange,Tadeusz F. Molinski,Christian Griesinger +5 more
TL;DR: The proposed NMR method relies on the measurement of dipolar couplings in recently introduced alignment media that are compatible with organic solvents, and cross validating the NMR determined ensemble of conformations against the residual dipolars couplings.
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β-Barrel Mobility Underlies Closure of the Voltage-Dependent Anion Channel
Ulrich Zachariae,Ulrich Zachariae,Robert Schneider,Rodolfo Briones,Zrinka Gattin,Jean-Philippe Demers,Karin Giller,Elke Maier,Markus Zweckstetter,Christian Griesinger,Stefan Becker,Roland Benz,Roland Benz,Bert L. de Groot,Adam Lange +14 more
TL;DR: In this article, the authors show that deletion of the rigid N-terminal helix sharply increases overall motion in VDAC's β-barrel, resulting in elliptic, semicollapsed barrel shapes.