C
Christian Griesinger
Researcher at Max Planck Society
Publications - 449
Citations - 25595
Christian Griesinger is an academic researcher from Max Planck Society. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Residual dipolar coupling. The author has an hindex of 76, co-authored 408 publications receiving 23162 citations. Previous affiliations of Christian Griesinger include University of Göttingen & ETH Zurich.
Papers
More filters
Journal ArticleDOI
Mass spectrometric sequencing of individual peptides from combinatorial libraries via specific generation of chain-terminated sequences.
TL;DR: A method of rapid and unambiguous peptide sequencing by utilizing synthesis-implemented generation of termination sequences with subsequent matrix-assisted laser desorption ionization time of flight (MALDI-TOF) mass spectrometric analysis is introduced here.
Journal ArticleDOI
A Combination of Spin Diffusion Methods for the Determination of Protein–Ligand Complex Structural Ensembles
Jens Pilger,Adam Mazur,Peter Monecke,Herman Schreuder,Bettina Elshorst,Stefan Bartoschek,Thomas Langer,Alexander Schiffer,Isabelle Krimm,Melanie Wegstroth,Donghan Lee,Gerhard Hessler,K-Ulrich Wendt,Stefan Becker,Christian Griesinger +14 more
TL;DR: The combination of the spin-diffusion-based NMR methods INPHARMA, trNOE, and STD results in an accurate scoring function for docking modes and therefore determination of protein-ligand complex structures.
Journal ArticleDOI
De novo fragment-based design of inhibitors of DXS guided by spin-diffusion-based NMR spectroscopy
Tiziana Masini,J. Pilger,B. S. Kroezen,Boris Illarionov,P. Lottmann,Markus Fischer,Christian Griesinger,Anna K. H. Hirsch +7 more
TL;DR: The STI methodology proved its strong potential as a tool to support medicinal-chemistry projects in their early stages, especially when dealing with weak binders.
Journal ArticleDOI
Relative configuration of micrograms of natural compounds using proton residual chemical shift anisotropy.
Nilamoni Nath,Juan Carlos Fuentes-Monteverde,Dawrin Pech-Puch,Jaime Rodríguez,Carlos Jiménez,Markus Noll,Alexander Kreiter,Michael Reggelin,Armando Navarro-Vázquez,Christian Griesinger +9 more
TL;DR: 2H RCSAs are accurately measured using constrained aligning gels or liquid crystals and applied to the 3D structural determination of molecules with varying complexities and allow the elucidation of the relative configuration of a briarane compound isolated from Briareum asbestinum.
Journal ArticleDOI
A Dynamic Zinc Redox Switch
TL;DR: The crystal structures of Gfa and Gfa-GTT draw the critical association between a dynamic zinc redox switch and a nucleophilic addition as a new facet of the redox activity of zinc-sulfur sites.