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Christian Griesinger
Researcher at Max Planck Society
Publications - 449
Citations - 25595
Christian Griesinger is an academic researcher from Max Planck Society. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Residual dipolar coupling. The author has an hindex of 76, co-authored 408 publications receiving 23162 citations. Previous affiliations of Christian Griesinger include University of Göttingen & ETH Zurich.
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Journal ArticleDOI
Effect of the Solvent on the Conformation of a Depsipeptide: NMR‐Derived Solution Structure of Hormaomycin in DMSO from Residual Dipolar Couplings in a Novel DMSO‐Compatible Alignment Medium
Uwe M. Reinscheid,Jonathan Farjon,Markus Radzom,Peter Haberz,Axel Zeeck,Martin Blackledge,Christian Griesinger +6 more
TL;DR: Measurement of residual dipolar couplings induced by dissolving the depsipeptide in a polyacrylamide gel compatible with DMSO and their incorporation into the structure calculation of the title compound improved the precision of the family of structures.
Journal ArticleDOI
11 C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α-Synuclein Fibrils in vitro and Crosses the Blood-Brain Barrier.
Andreas Maurer,Andrei Leonov,Sergey Ryazanov,Kristina Herfert,Laura Kuebler,Sabrina Buss,Felix Schmidt,Daniel Weckbecker,Ruth Linder,Dirk Bender,Armin Giese,Bernd J. Pichler,Christian Griesinger +12 more
TL;DR: High‐affinity binding of the family member anle253b to fibrillar αSyn is demonstrated and a high‐yielding site‐selective radiosynthesis route for 11C radiolabeling using in‐situ generated [11C]formaldehyde and reductive methylation is presented.
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Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization
Antonio Dominguez-Meijide,Antonio Dominguez-Meijide,Eftychia Vasili,Annekatrin König,Maria-Sol Cima-Omori,Alain Ibáñez de Opakua,Andrei Leonov,Sergey Ryazanov,Markus Zweckstetter,Markus Zweckstetter,Markus Zweckstetter,Christian Griesinger,Tiago F. Outeiro,Tiago F. Outeiro,Tiago F. Outeiro +14 more
TL;DR: The effects of different pharmacological interventions on the aggregation and internalization of tau and aSyn are assessed and it is found that anle138b and fulvic acid decrease aSyn and tau aggregation, that epigallocatechin gallate decreases aSyn aggregation, and that dynasore reduces tau internalization.
Journal ArticleDOI
Structure, gating and interactions of the voltage-dependent anion channel
Eszter E. Najbauer,Stefan Becker,Karin Giller,Markus Zweckstetter,Markus Zweckstetter,Adam Lange,Claudia Steinem,Claudia Steinem,Bert L. de Groot,Christian Griesinger,Loren B. Andreas +10 more
TL;DR: The sensitivity of VDAC structure to variations in the membrane environment is explored, comparing DMPC-only, DMPC with cholesterol, and near-native lipid compositions, and using magic-angle spinning NMR spectroscopy to locate cholesterol on the outside of the β-barrel.