C
Christian Griesinger
Researcher at Max Planck Society
Publications - 449
Citations - 25595
Christian Griesinger is an academic researcher from Max Planck Society. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Residual dipolar coupling. The author has an hindex of 76, co-authored 408 publications receiving 23162 citations. Previous affiliations of Christian Griesinger include University of Göttingen & ETH Zurich.
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Journal ArticleDOI
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
Ana Martinez Hernandez,Ana Martinez Hernandez,Hendrik Urbanke,Alan L. Gillman,Joon Lee,Sergey Ryazanov,Sergey Ryazanov,Hope Y Agbemenyah,Eva Benito,Gaurav Jain,Lalit Kaurani,Gayane Grigorian,Andrei Leonov,Andrei Leonov,Nasrollah Rezaei-Ghaleh,Nasrollah Rezaei-Ghaleh,Petra Wilken,Petra Wilken,Fernando Teran Arce,Jens Wagner,Martin Fuhrman,Mario Caruana,Angelique Camilleri,Neville Vassallo,Markus Zweckstetter,Roland Benz,Armin Giese,Anja Schneider,Anja Schneider,Martin Korte,Ratnesh Lal,Christian Griesinger,Christian Griesinger,Gregor Eichele,Andre Fischer,Andre Fischer +35 more
TL;DR: It is shown that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology.
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Novel strategies for sensitivity enhancement in heteronuclear multi—dimensional NMR experiments employing pulsed field gradients
TL;DR: It is shown that in 3D sequences employing several Coherence Order Selective Coherence Transfer (COS-CT) steps, enhancement factors of up to 2 can be achieved, compatible with the use of heteronuclear gradient echoes, yielding spectra with excellent water suppression.
Journal ArticleDOI
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies
Jens Wagner,Sybille Krauss,Song Shi,Sergey Ryazanov,Julia Steffen,Carolin Miklitz,Andrei Leonov,Alexander Kleinknecht,Bettina Göricke,Jochen H. Weishaupt,Daniel Weckbecker,Anne Reiner,Wolfgang Zinth,Johannes Levin,Dan Ehninger,Stefan Remy,Hans A. Kretzschmar,Christian Griesinger,Armin Giese,Martin Fuhrmann +19 more
TL;DR: It is shown that the di-phenyl-pyrazole anle 138b binds to aggregated tau and inhibits tau aggregation in vitro and in vivo and that reducing tau aggregates with anle138b may represent an effective and promising approach for the treatment of human tauopathies.
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The Native Conformation of the Human VDAC1 N Terminus
Robert Schneider,Manuel Etzkorn,Karin Giller,Venita Daebel,Jörg Eisfeld,Markus Zweckstetter,Christian Griesinger,Stefan Becker,Adam Lange +8 more
TL;DR: Functional human VDAC1 in lipid bilayers is investigated using solid-state NMR spectroscopy, with a focus on the conformation of its N terminus, which indicates that the overall 19-stranded b-barrel fold is conserved in liposomes.
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1H and 13C Dynamic Nuclear Polarization in Aqueous Solution with a Two-Field (0.35 T/14 T) Shuttle DNP Spectrometer
Marcel Reese,Maria-Teresa Türke,Igor Tkach,Giacomo Parigi,Claudio Luchinat,Thorsten Marquardsen,Andreas Tavernier,Peter Höfer,Frank Engelke,Christian Griesinger,Marina Bennati +10 more
TL;DR: A proof of principle for the feasibility of a shuttle DNP experiment is provided and perspectives for the application potential of this method in solution NMR are opened up.