Christian Griesinger

TL;DR: In this paper , the authors investigated the molecular diffusivity of reactants, catalyst, and product of a model reaction, the copper-catalyzed azide-alkyne cycloaddition click reaction, and developed new NMR diffusion approaches that allow the probing of reaction-induced diffusion enhancement in nanosized molecular systems with higher accuracy than the state of the art.

TL;DR: The results suggest piston-type TM signaling by the TM2 homodimer from PASP across the full TM region, whereas the fumarate-destabilized linker dimer converts the signal on the cytoplasmic side for PASC and kinase regulation.

TL;DR: The binding site of the DPP anle138b in protein aggregates is characterized and contribute to the understanding of the therapeutic mode of action of this compound.

TL;DR: In this article, a combination of para-hydrogen enhanced magnetic resonance with the phenomenon of the RASER was introduced, where large signals of solvent molecules interact with the magnetic resonance coil in a way that the signal is spontaneously converted into an in-phase signal.

TL;DR: A system for the creation of inducibly αSyn-overexpressing cell lines holding high potential for the screening for modulators of αSyn aggregation and α synuclein-mediated toxicity is presented.