C
Christian Griesinger
Researcher at Max Planck Society
Publications - 449
Citations - 25595
Christian Griesinger is an academic researcher from Max Planck Society. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Residual dipolar coupling. The author has an hindex of 76, co-authored 408 publications receiving 23162 citations. Previous affiliations of Christian Griesinger include University of Göttingen & ETH Zurich.
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Resolving the Atomistic Modes of Anle138b Inhibitory Action on Peptide Oligomer Formation.
TL;DR: It is demonstrated that the hydrogen bonding capabilities are autoinhibited due to steric effects imposed by the molecular geometry of anle234b and thereby indirectly confirm the proposed inhibitory mechanism of the diphenyl-pyrazole compound anle138b.
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Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau
Matthias Brendel,Maximilian Deussing,Tanja Blume,Tanja Blume,Lena Kaiser,Federico Probst,Felix Overhoff,Finn Peters,Barbara von Ungern-Sternberg,Sergey Ryazanov,Andrei Leonov,Christian Griesinger,Christian Griesinger,Andreas Zwergal,Johannes Levin,Peter Bartenstein,Igor Yakushev,Paul Cumming,Guido Boening,Sibylle Ziegler,Jochen Herms,Jochen Herms,Armin Giese,Axel Rominger +23 more
TL;DR: Late-stage oligomer modulation effectively ameliorated tau pathology in hTau mice and rescued metabolic function and molecular imaging by FDG-PET can serve for monitoring effects of Anle138b treatment.
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Long-Range Distances in Amyloid Fibrils of α-Synuclein from PELDOR Spectroscopy†
Soraya Pornsuwan,Karin Giller,Dietmar Riedel,Stefan Becker,Christian Griesinger,Marina Bennati +5 more
TL;DR: Cell-to-cell transmission in nontransgenic mice points to a direct role of the fibrils in spreading the disease from peripheral to central neurons, and the molecular interactions that lead to misfolding strongly relies on the availability of suited biophysical methods that can access the structure of these states.
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A Two-Component Adhesive: Tau Fibrils Arise from a Combination of a Well-Defined Motif and Conformationally Flexible Interactions
ShengQi Xiang,Natalia Kulminskaya,Birgit Habenstein,Jacek Biernat,Katharina Tepper,Maria Paulat,Christian Griesinger,Stefan Becker,Adam Lange,Adam Lange,Adam Lange,Eckhard Mandelkow,Rasmus Linser +12 more
TL;DR: Solid-state NMR strategies providing assignments of non-seeded three-repeat-domain Tau3RD with an inherent heterogeneity revealed invariable secondary-structure properties, however, with inter-monomer interactions variable among samples.
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Structure and Absolute Configuration of Jurassic Polyketide-Derived Spiroborate Pigments Obtained from Microgram Quantities
TL;DR: The Jurassic borolithochromes now can be unambiguously linked to the modern polyketide, providing evidence that the fossil pigments are almost originally preserved secondary metabolites and suggesting that the pigments in fact may have been produced by an ancient bacterium.