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Christian Griesinger

Researcher at Max Planck Society

Publications -  449
Citations -  25595

Christian Griesinger is an academic researcher from Max Planck Society. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Residual dipolar coupling. The author has an hindex of 76, co-authored 408 publications receiving 23162 citations. Previous affiliations of Christian Griesinger include University of Göttingen & ETH Zurich.

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p160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain

TL;DR: It is shown that N coactivator family members are able to interact with other full-length NCoA proteins via their PAS-B domain and they specifically interact with the CBP-interaction domain (CID/AD1) of N CoA-1.
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Peptide ligands selected with CD4-induced epitopes on native dualtropic HIV-1 envelope proteins mimic extracellular coreceptor domains and bind to HIV-1 gp120 independently of coreceptor usage.

TL;DR: Interestingly, the optimized peptide could bind specifically to gp120 derived from HIV-1 strains with different coreceptor usage, competed with binding of CD4i-specific monoclonal antibody (MAb) 17b, and interfered with entry of both a CCR5 (R5)-tropic and a CXCR4 (X4-tropic Env pseudotyped virus.
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Interaction of Cu(I) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features

TL;DR: From the study of site-directed mutants and synthetic peptide models of αS, it is demonstrated the critical role played by Met-1 and Met-5 residues on the binding affinity of the Cu(i) complex, acting as the main metal anchoring residues.
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Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains

TL;DR: In this paper , the rotational correlation time (TRACT) measurements were used to map the dynamics of cohesive interactions in both phase-separated and soluble states at atomic resolution using TROSY.