C
Christian Grütter
Researcher at Technical University of Dortmund
Publications - 25
Citations - 2952
Christian Grütter is an academic researcher from Technical University of Dortmund. The author has contributed to research in topics: Kinase & MAP2K7. The author has an hindex of 21, co-authored 25 publications receiving 2610 citations. Previous affiliations of Christian Grütter include Max Planck Society & Vanderbilt University.
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Journal ArticleDOI
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Martin Peifer,Lynnette Fernandez-Cuesta,Martin L. Sos,Julie George,Danila Seidel,Lawryn H. Kasper,Dennis Plenker,Frauke Leenders,Ruping Sun,Thomas Zander,Roopika Menon,Mirjam Koker,Ilona Dahmen,Christian Müller,Vincenzo Di Cerbo,Hans Ulrich Schildhaus,Janine Altmüller,Ingelore Baessmann,Christian Becker,Bram De Wilde,Jo Vandesompele,Diana Böhm,Sascha Ansén,Franziska Gabler,Ines Wilkening,Stefanie Heynck,Johannes M. Heuckmann,Xin Lu,Scott L. Carter,Kristian Cibulskis,Shantanu Banerji,Gad Getz,Kwon-Sik Park,Daniel Rauh,Christian Grütter,Matthias Fischer,Laura Pasqualucci,Gavin M. Wright,Zoe Wainer,Prudence A. Russell,Iver Petersen,Yuan Chen,Erich Stoelben,Corinna Ludwig,Philipp A. Schnabel,Hans Hoffmann,Thomas Muley,Michael Brockmann,Walburga Engel-Riedel,Lucia Anna Muscarella,Vito Michele Fazio,Harry J.M. Groen,Wim Timens,Hannie Sietsma,Erik Thunnissen,Egber Smit,Daniëlle A M Heideman,Peter J.F. Snijders,Federico Cappuzzo,C. Ligorio,Stefania Damiani,John K. Field,Steinar Solberg,Odd Terje Brustugun,Marius Lund-Iversen,Jörg Sänger,Joachim H. Clement,Alex Soltermann,Holger Moch,Walter Weder,Benjamin Solomon,Jean-Charles Soria,Pierre Validire,Benjamin Besse,Elisabeth Brambilla,Christian Brambilla,Sylvie Lantuejoul,Philippe Lorimier,Peter M. Schneider,Michael Hallek,William Pao,Matthew Meyerson,Matthew Meyerson,Julien Sage,Jay Shendure,Robert Schneider,Robert Schneider,Reinhard Büttner,Jürgen Wolf,Peter Nürnberg,Sven Perner,Lukas C. Heukamp,Paul K. Brindle,Stefan A. Haas,Roman K. Thomas +94 more
TL;DR: This study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background.
Journal ArticleDOI
Natural-product-derived fragments for fragment-based ligand discovery.
Björn Over,Stefan Wetzel,Christian Grütter,Yasushi Nakai,Steffen Renner,Daniel Rauh,Herbert Waldmann +6 more
TL;DR: A library of 2,000 natural-product-derived fragments with high structural diversity, which resemble the properties of the natural products themselves and give access to novel inhibitor chemotypes are produced.
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ALK Mutations Conferring Differential Resistance to Structurally Diverse ALK Inhibitors
Johannes M. Heuckmann,Michael Hölzel,Martin L. Sos,Stefanie Heynck,Hyatt Balke-Want,Mirjam Koker,Martin Peifer,Jonathan Weiss,Christine M. Lovly,Christian Grütter,Daniel Rauh,William Pao,Roman K. Thomas +12 more
TL;DR: The results show that different ALK resistance mutations as well as different AlK inhibitors impact the therapeutic efficacy in the setting of EML4–ALK fusions and ALK mutations.
Journal ArticleDOI
Strategies for the Selective Regulation of Kinases with Allosteric Modulators: Exploiting Exclusive Structural Features
TL;DR: This review highlights various strategies that have been developed to utilizing exclusive structural features of kinases and thereby modulating their activity allosterically and thought to provide various advantages such as higher selectivity and extended drug target residence times.
Journal ArticleDOI
Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.
Jeffrey R. Simard,Matthäus Getlik,Christian Grütter,Vijaykumar Pawar,Sabine Wulfert,Matthias Rabiller,Daniel Rauh +6 more
TL;DR: A fluorescence-based kinase binding assay for identifying and characterizing ligands which stabilize the inactive kinase conformation is developed and validation of this assay using the serine/threonine kinase p38alpha is presented.