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Vincenzo Di Cerbo
Researcher at Max Planck Society
Publications - 6
Citations - 1570
Vincenzo Di Cerbo is an academic researcher from Max Planck Society. The author has contributed to research in topics: Histone code & Chromatin remodeling. The author has an hindex of 5, co-authored 6 publications receiving 1299 citations. Previous affiliations of Vincenzo Di Cerbo include Centre national de la recherche scientifique & Guy's Hospital.
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Journal ArticleDOI
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Martin Peifer,Lynnette Fernandez-Cuesta,Martin L. Sos,Julie George,Danila Seidel,Lawryn H. Kasper,Dennis Plenker,Frauke Leenders,Ruping Sun,Thomas Zander,Roopika Menon,Mirjam Koker,Ilona Dahmen,Christian Müller,Vincenzo Di Cerbo,Hans Ulrich Schildhaus,Janine Altmüller,Ingelore Baessmann,Christian Becker,Bram De Wilde,Jo Vandesompele,Diana Böhm,Sascha Ansén,Franziska Gabler,Ines Wilkening,Stefanie Heynck,Johannes M. Heuckmann,Xin Lu,Scott L. Carter,Kristian Cibulskis,Shantanu Banerji,Gad Getz,Kwon-Sik Park,Daniel Rauh,Christian Grütter,Matthias Fischer,Laura Pasqualucci,Gavin M. Wright,Zoe Wainer,Prudence A. Russell,Iver Petersen,Yuan Chen,Erich Stoelben,Corinna Ludwig,Philipp A. Schnabel,Hans Hoffmann,Thomas Muley,Michael Brockmann,Walburga Engel-Riedel,Lucia Anna Muscarella,Vito Michele Fazio,Harry J.M. Groen,Wim Timens,Hannie Sietsma,Erik Thunnissen,Egber Smit,Daniëlle A M Heideman,Peter J.F. Snijders,Federico Cappuzzo,C. Ligorio,Stefania Damiani,John K. Field,Steinar Solberg,Odd Terje Brustugun,Marius Lund-Iversen,Jörg Sänger,Joachim H. Clement,Alex Soltermann,Holger Moch,Walter Weder,Benjamin Solomon,Jean-Charles Soria,Pierre Validire,Benjamin Besse,Elisabeth Brambilla,Christian Brambilla,Sylvie Lantuejoul,Philippe Lorimier,Peter M. Schneider,Michael Hallek,William Pao,Matthew Meyerson,Matthew Meyerson,Julien Sage,Jay Shendure,Robert Schneider,Robert Schneider,Reinhard Büttner,Jürgen Wolf,Peter Nürnberg,Sven Perner,Lukas C. Heukamp,Paul K. Brindle,Stefan A. Haas,Roman K. Thomas +94 more
TL;DR: This study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background.
Journal ArticleDOI
Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription
Vincenzo Di Cerbo,Vincenzo Di Cerbo,Fabio Mohn,Daniel P. Ryan,Emilie Montellier,Salim Kacem,Philipp Tropberger,Philipp Tropberger,Eleni Kallis,Monika Holzner,Leslie Hoerner,Angelika Feldmann,Florian Richter,Andrew J. Bannister,Andrew J. Bannister,Gerhard Mittler,Jens Michaelis,Saadi Khochbin,Robert Feil,Dirk Schuebeler,Tom Owen-Hughes,Sylvain Daujat,Robert Schneider +22 more
TL;DR: It is demonstrated that H3K64ac is enriched in vivo at the transcriptional start sites of active genes and it defines transcriptionally active chromatin, and an important role for a histone modification within the nucleosome core as a regulator of chromatin function is revealed.
Journal ArticleDOI
Cancers with wrong HATs: the impact of acetylation.
TL;DR: With the use of histone deacetylase inhibitors and acetylation modulators (e.g. HAT inhibitors, bromodomain inhibitors), this work is paving the way for a future epigenetic drug control of human diseases.
Journal ArticleDOI
The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin
David Brown,Vincenzo Di Cerbo,Angelika Feldmann,Jae-Woo Ahn,Shinsuke Ito,Neil P. Blackledge,Manabu Nakayama,Michael McClellan,Emilia Dimitrova,Anne H. Turberfield,Hannah K. Long,Hamish W King,Skirmantas Kriaucionis,Lothar Schermelleh,Tatiana G. Kutateladze,Haruhiko Koseki,Robert J. Klose +16 more
TL;DR: It is discovered that the vertebrate SET1 complex is targeted to actively transcribed gene promoters through CFP1, which engages in a form of multivalent chromatin reading that involves recognition of non-methylated DNA and histone H3 lysine 4 trimethylation.
Journal ArticleDOI
Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells.
Paola Bontempo,Luigi Mita,Antonella Doto,Marco Miceli,Angela Nebbioso,Ilaria Lepore,Gianluigi Franci,Roberta Menafra,Vincenzo Carafa,Mariarosaria Conte,Floriana De Bellis,Fabio Manzo,Vincenzo Di Cerbo,Rosaria Benedetti,Loredana D’Amato,Maria Marino,Alessandro Bolli,Giovanna Del Pozzo,Nadia Diano,Marianna Portaccio,Gustavo D Mita,Maria Teresa Vietri,Michele Cioffi,E. Nola,Carmela Dell'Aversana,Vincenzo Sica,Anna Maria Molinari,Lucia Altucci +27 more
TL;DR: BPA is able to induce apoptosis in leukemia cells via caspase activation and involvement of both intrinsic and extrinsic pathways of apoptosis, indicating that a complex intersection of regulations occur for the apoptotic action of BPA.