Diana Böhm

TL;DR: This study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background.

TL;DR: FGFR1 dependency is frequent across various lung cancer histologies, and FGFR 1 mRNA may serve as a better biomarker of FGFR TKI response in lung cancer than FGFR1 GCN.

TL;DR: This analysis revealed distinct transcriptional expression profiles of the Mediator complex across cancer entities indicating differential modes of transcriptional regulation and identified CDK19 and CDK8 to be specifically overexpressed during prostate cancer progression, highlighting their potential as novel therapeutic targets in advanced prostate cancer.

TL;DR: The results of the present study underscore that typing of CaP for the ERG could enhance the understanding of the biologic differences between the examined ethnic groups, and establish a major difference between the index tumors of Caucasian and African American patients.

TL;DR: TRUP (Tumor-specimen suited RNA-seq Unified Pipeline) is developed, a computational approach that combines split-read and read-pair analysis with de novo assembly for the identification of chimeric transcripts in cancer specimens and is found to be more sensitive than alternative tools in detecting chimeric Transcripts.