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Christian J. Buhay
Researcher at Baylor College of Medicine
Publications - 33
Citations - 31180
Christian J. Buhay is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Genome & Exome sequencing. The author has an hindex of 29, co-authored 33 publications receiving 27910 citations. Previous affiliations of Christian J. Buhay include Human Genome Sequencing Center.
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Journal ArticleDOI
Genome Project Standards in a New Era of Sequencing
Patrick S. G. Chain,Darren Grafham,Robert S. Fulton,Michael Fitzgerald,Jessica B. Hostetler,Donna M. Muzny,Johar Ali,Bruce W. Birren,D. C. Bruce,D. C. Bruce,Christian J. Buhay,James R. Cole,Yan Ding,Shannon Dugan,Dawn Field,George M. Garrity,Richard A. Gibbs,Tina GravesT. Graves,Cliff S. Han,Cliff S. Han,Scott H. Harrison,Sarah K. Highlander,Philip Hugenholtz,H. M. Khouri,Chinnappa D. Kodira,Eugene Kolker,Nikos C. Kyrpides,D. Lang,Alla Lapidus,S. A. Malfatti,Victor Markowitz,T. Metha,Karen E. Nelson,Julian Parkhill,Samuel Pitluck,Xiang Qin,Timothy D. Read,Jeremy Schmutz,Shanmuga Sozhamannan,Peter Sterk,Robert L. Strausberg,Granger G. Sutton,Nicholas R. Thomson,James M. Tiedje,George M. Weinstock,Aye Wollam,John C. Detter +46 more
TL;DR: In this article, the authors propose a method to distinguish good from poor data sets by navigating through the databases to find the number and type of reads deposited in sequence trace repositories (and not all genomes have this available), or to identify the number of contigs or genome fragments deposited to the database.
Journal ArticleDOI
Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF
Agathe Bourgogne,Danielle A. Garsin,Xiang Qin,Kavindra V. Singh,Jouko Sillanpää,Shailaja Yerrapragada,Yan Ding,Shannon Dugan-Rocha,Christian J. Buhay,Hua Shen,Guan Chen,Gabrielle Williams,Donna M. Muzny,Arash Maadani,Kristina A. Fox,Jason Gioia,Lei Chen,Yue Shang,Cesar A. Arias,Sreedhar R. Nallapareddy,Meng Zhao,Vittal P. Prakash,Shahreen Chowdhury,Huaiyang Jiang,Richard A. Gibbs,Barbara E. Murray,Sarah K. Highlander,George M. Weinstock +27 more
TL;DR: OG1RF's effects in experimental models suggest that mediators of virulence may be diverse between different E. faecalis strains and that virulence is not dependent on the presence of mobile genetic elements.
Journal ArticleDOI
Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes
Jennifer F. Hughes,Helen Skaletsky,Laura G. Brown,Tatyana Pyntikova,Tina Graves,Robert S. Fulton,Shannon Dugan,Yan Ding,Christian J. Buhay,Colin Kremitzki,Qiaoyan Wang,Hua Shen,Michael Holder,Donna Villasana,Lynne V. Nazareth,Andrew Cree,Laura Courtney,Joelle Veizer,Holland Kotkiewicz,Ting-Jan Cho,Natalia Koutseva,Steve Rozen,Donna M. Muzny,Wesley C. Warren,Richard A. Gibbs,Richard K. Wilson,David C. Page +26 more
TL;DR: An empirical reconstruction of human MSY evolution is presented, in which each stratum transitioned from rapid, exponential loss of ancestral genes to strict conservation through purifying selection.
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Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus
Sarah K. Highlander,Kristina G. Hulten,Xiang Qin,Huaiyang Jiang,Shailaja Yerrapragada,Edward O. Mason,Yue Shang,Tiffany M. Williams,Regine M. Fortunov,Yamei Liu,Okezie C. Igboeli,Joseph F. Petrosino,Madhan R. Tirumalai,Akif Uzman,George E. Fox,Ana Maria Cardenas,Donna M. Muzny,Lisa Hemphill,Yan Ding,Shannon Dugan,Peter R Blyth,Christian J. Buhay,Huyen Dinh,Alicia Hawes,Michael Holder,Christie Kovar,Sandra L. Lee,Wen Liu,Lynne V. Nazareth,Qiaoyan Wang,Jianling Zhou,Sheldon L. Kaplan,George M. Weinstock +32 more
TL;DR: USA300-MRSA is highly similar to other MRSA strains based on whole genome alignments and gene content, indicating that the differences in pathogenesis are due to subtle changes rather than to large-scale acquisition of virulence factor genes.
Journal ArticleDOI
Launching genomics into the cloud: deployment of Mercury, a next generation sequence analysis pipeline.
Jeffrey G. Reid,Andrew Carroll,Narayanan Veeraraghavan,Mahmoud Dahdouli,Andreas Sundquist,Adam C. English,Matthew N. Bainbridge,Simon D. M. White,William J Salerno,Christian J. Buhay,Fuli Yu,Donna M. Muzny,Richard Daly,Geoff Duyk,Richard A. Gibbs,Eric Boerwinkle,Eric Boerwinkle +16 more
TL;DR: The Mercury analysis pipeline is developed and deployed in local hardware and the Amazon Web Services cloud via the DNAnexus platform and provides accurate and reproducible genomic results at scales ranging from individuals to large cohorts.