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Christian M. K. Sieber
Researcher at Joint Genome Institute
Publications - 34
Citations - 2651
Christian M. K. Sieber is an academic researcher from Joint Genome Institute. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 21, co-authored 32 publications receiving 1827 citations. Previous affiliations of Christian M. K. Sieber include Lawrence Berkeley National Laboratory & University of California, Berkeley.
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Journal ArticleDOI
Recovery of genomes from metagenomes via a dereplication, aggregation and scoring strategy.
Christian M. K. Sieber,Christian M. K. Sieber,Alexander J. Probst,Allison Sharrar,Brian C. Thomas,Matthias Hess,Susannah G. Tringe,Jillian F. Banfield +7 more
TL;DR: A tool that enables a flexible set of existing binning algorithms to be combined, resulting in improved binning accuracy and the recovery of more near-complete genomes from metagenomes compared to standalone methods is presented.
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Deciphering the cryptic genome : genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites
Philipp Wiemann,Christian M. K. Sieber,Katharina Walburga von Bargen,Lena Studt,Eva-Maria Niehaus,José J. Espino,Kathleen Huß,Caroline B. Michielse,Sabine Albermann,Dominik Wagner,Sonja Verena Bergner,Lanelle R. Connolly,Andreas Fischer,Gunter Reuter,Karin Kleigrewe,Till Bald,Brenda D. Wingfield,Ron Ophir,Stanley Freeman,Michael Hippler,Kristina M. Smith,Daren W. Brown,Robert H. Proctor,Martin Münsterkötter,Michael Freitag,Hans-Ulrich Humpf,Ulrich Güldener,Bettina Tudzynski +27 more
TL;DR: Combined comparative genomics and genome-wide experimental analyses identified novel genes and secondary metabolites that contribute to the evolutionary success of F. fujikuroi as a rice pathogen.
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Differential depth distribution of microbial function and putative symbionts through sediment-hosted aquifers in the deep terrestrial subsurface
Alexander J. Probst,Alexander J. Probst,Bethany Ladd,Jessica K. Jarett,David Geller-McGrath,Christian M. K. Sieber,Christian M. K. Sieber,Joanne B. Emerson,Joanne B. Emerson,Karthik Anantharaman,Brian C. Thomas,Rex R. Malmstrom,Michaela Stieglmeier,Andreas Klingl,Tanja Woyke,M. Cathryn Ryan,Jillian F. Banfield +16 more
TL;DR: Analysis of a CO2-driven geyser over a complete eruption cycle showed temporal changes in microbial community composition and function, associated with eruption phase and aquifer water depth, and revealed a putative archaeal symbiosis.
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Wide diversity of methane and short-chain alkane metabolisms in uncultured archaea.
Guillaume Borrel,Panagiotis S. Adam,Panagiotis S. Adam,Luke J. McKay,Lin-Xing Chen,Isabel N. Sierra-Garcia,Christian M. K. Sieber,Christian M. K. Sieber,Quentin Letourneur,Amine Ghozlane,Gary L. Andersen,Wen-Jun Li,Steven J. Hallam,Gerard Muyzer,Valéria Maia de Oliveira,William P. Inskeep,Jillian F. Banfield,Simonetta Gribaldo +17 more
TL;DR: A search for methyl-coenzyme M reductase complex (MCR) and MCR-like homologues—which govern methane and short-chain alkane metabolism—across publicly available metagenomes reveals that these metabolic pathways are widespread and diverse in archaea, and may in some organisms be linked to alkane and/or fatty acid oxidation.
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A tale of genome compartmentalization: the evolution of virulence clusters in smut fungi.
Julien Y. Dutheil,Gertrud Mannhaupt,Gabriel Schweizer,Christian M. K. Sieber,Martin Münsterkötter,Ulrich Güldener,Jan Schirawski,Regine Kahmann +7 more
TL;DR: It is shown that the genome of S. scitamineum, a smut fungus parasitizing sugar cane with a phylogenetic position intermediate to the two previously sequenced species U. maydis and Sporisorium reilianum, contains more and larger gene clusters encoding secreted effectors than any previously described species in this group.