J
Jaromír Mikeš
Researcher at Science for Life Laboratory
Publications - 71
Citations - 2986
Jaromír Mikeš is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Hypericin & Apoptosis. The author has an hindex of 25, co-authored 70 publications receiving 1966 citations. Previous affiliations of Jaromír Mikeš include University of Pavol Jozef Šafárik & Karolinska University Hospital.
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Journal ArticleDOI
Stereotypic Immune System Development in Newborn Children
Axel Olin,Ewa Henckel,Yang Chen,Tadepally Lakshmikanth,Christian Pou,Jaromír Mikeš,Anna Gustafsson,Anna Gustafsson,Anna Karin Bernhardsson,Cheng Zhang,Kajsa Bohlin,Kajsa Bohlin,Petter Brodin,Petter Brodin +13 more
TL;DR: This article performed longitudinal analyses in 100 newborn children, sampled up to 4 times during their first 3 months of life, and analyzed the development of 58 immune cell populations by mass cytometry and 267 plasma proteins by immunoassays.
Journal ArticleDOI
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells
Mathias Uhlén,Mathias Uhlén,Mathias Uhlén,Max J. Karlsson,Wen Zhong,Abdellah Tebani,Christian Pou,Jaromír Mikeš,Tadepally Lakshmikanth,Björn Forsström,Fredrik Edfors,Jacob Odeberg,Jacob Odeberg,Adil Mardinoglu,Adil Mardinoglu,Cheng Zhang,Kalle von Feilitzen,Jan Mulder,Evelina Sjöstedt,Andreas Hober,Per Oksvold,Martin Zwahlen,Fredrik Pontén,Cecilia Lindskog,Åsa Sivertsson,Linn Fagerberg,Petter Brodin,Petter Brodin +27 more
TL;DR: The cellular distribution of genes known to cause primary immunodeficiencies in humans are shown and find that many of these genes are expressed in cells not currently implicated in these diseases, illustrating how this global atlas can help us better understand the function of specific genes across cells and tissues in humans.
Journal ArticleDOI
Bifidobacteria-mediated immune system imprinting early in life.
Bethany M. Henrick,Lucie Rodriguez,Tadepally Lakshmikanth,Christian Pou,Ewa Henckel,Ewa Henckel,Ewa Henckel,Aron Arzoomand,Axel Olin,Jun Wang,Jaromír Mikeš,Ziyang Tan,Yang Chen,Amy M. Ehrlich,Anna Karin Bernhardsson,Constantin Habimana Mugabo,Ylva Ambrosiani,Anna Gustafsson,Anna Gustafsson,Stephanie Chew,Heather Brown,Johann Prambs,Kajsa Bohlin,Kajsa Bohlin,Ryan D. Mitchell,Mark A. Underwood,Jennifer T. Smilowitz,J. Bruce German,Steven A. Frese,Steven A. Frese,Petter Brodin,Petter Brodin +31 more
TL;DR: This article showed that a lack of bifidobacteria, and in particular depletion of genes required for human milk oligosaccharide utilization from the metagenome, is associated with systemic inflammation and immune dysregulation early in life.
Posted ContentDOI
Bifidobacteria-mediated immune system imprinting early in life
Bethany M. Henrick,Lucie Rodriguez,Tadepally Lakshmikanth,Christian Pou,Ewa Henckel,Ewa Henckel,Ewa Henckel,Axel Olin,Jun Wang,Jaromír Mikeš,Ziyang Tan,Yang Chen,Amy M. Ehrlich,Anna Karin Bernhardsson,Constantin Habimana Mugabo,Ylva Ambrosiani,Anna Gustafsson,Anna Gustafsson,Stephanie Chew,Heather Brown,Johann Prambs,Kajsa Bohlin,Kajsa Bohlin,Ryan D. Mitchell,Mark A. Underwood,Jennifer T. Smilowitz,J. Bruce German,Steven A. Frese,Petter Brodin,Petter Brodin +29 more
TL;DR: An ordered sequence of immune changes after birth, driven by microbial interactions is mapped, triggered by microbial colonization that distinguish children with different gut bacterial composition.
Journal ArticleDOI
Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid.
TL;DR: A differential sensitivity of cancer cell lines to lichen secondary metabolites is confirmed and the suppression of viability and cell proliferation by usnic acid or atranorin was found to be more efficient at equitoxic doses and correlated more strongly with an increased number of floating cells or a higher apoptotic index.