C
Christopher T. Harbison
Researcher at Massachusetts Institute of Technology
Publications - 9
Citations - 9443
Christopher T. Harbison is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Regulation of gene expression & Gene. The author has an hindex of 7, co-authored 9 publications receiving 9194 citations.
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Journal ArticleDOI
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
Tong Ihn Lee,Nicola J. Rinaldi,François Robert,Duncan T. Odom,Ziv Bar-Joseph,Georg K. Gerber,Nancy M. Hannett,Christopher T. Harbison,Craig M. Thompson,Itamar Simon,Julia Zeitlinger,Ezra G. Jennings,Heather L. Murray,D. Benjamin Gordon,Bing Ren,John J. Wyrick,Jean-Bosco Tagne,Thomas L. Volkert,Ernest Fraenkel,David K. Gifford,Richard A. Young +20 more
TL;DR: This work determines how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells, and identifies network motifs, the simplest units of network architecture, and demonstrates that an automated process can use motifs to assemble a transcriptional regulatory network structure.
Journal ArticleDOI
Transcriptional regulatory code of a eukaryotic genome
Christopher T. Harbison,D. Benjamin Gordon,Tong Ihn Lee,Nicola J. Rinaldi,Kenzie D MacIsaac,Timothy Danford,Nancy M. Hannett,Jean-Bosco Tagne,David B. Reynolds,Jane Yoo,Ezra G. Jennings,Julia Zeitlinger,Dmitry K. Pokholok,Manolis Kellis,Manolis Kellis,P. Alex Rolfe,Ken T. Takusagawa,Eric S. Lander,Eric S. Lander,David K. Gifford,David K. Gifford,Ernest Fraenkel,Richard A. Young,Richard A. Young +23 more
TL;DR: An initial map of yeast's transcriptional regulatory code is constructed by identifying the sequence elements that are bound by regulators under various conditions and that are conserved among Saccharomyces species.
Journal ArticleDOI
Genome-wide map of nucleosome acetylation and methylation in yeast.
Dmitry K. Pokholok,Christopher T. Harbison,Stuart S. Levine,Megan F. Cole,Nancy M. Hannett,Tong Ihn Lee,George W. Bell,Kimberly Walker,P. Alex Rolfe,Elizabeth Herbolsheimer,Julia Zeitlinger,Fran Lewitter,David K. Gifford,Richard A. Young +13 more
TL;DR: These maps take into account changes in nucleosome occupancy at actively transcribed genes and, in doing so, revise previous assessments of the modifications associated with gene expression, providing the foundation for further understanding the roles of chromatin in gene expression and genome maintenance.
Journal ArticleDOI
Remodeling of Yeast Genome Expression in Response to Environmental Changes
Helen C. Causton,Bing Ren,Sang Seok Koh,Christopher T. Harbison,Elenita I. Kanin,Ezra G. Jennings,Tong Ihn Lee,Heather L. True,Eric S. Lander,Richard A. Young +9 more
TL;DR: The results of expression analysis with MSN2/MSN4 mutants support the model that the Msn2/Msn4 activators induce the common response to environmental change and extend the understanding of the role of activators in effecting this response.
Journal ArticleDOI
Serial Regulation of Transcriptional Regulators in the Yeast Cell Cycle
Itamar Simon,John D. Barnett,Nancy M. Hannett,Christopher T. Harbison,Nicola J. Rinaldi,Thomas L. Volkert,John J. Wyrick,Julia Zeitlinger,David K. Gifford,Tommi S. Jaakkola,Richard A. Young +10 more
TL;DR: Genome-wide location analysis was used to determine how the yeast cell cycle gene expression program is regulated by each of the nine known cell cycle transcriptional activators, and revealed how the nine transcriptional regulators coordinately regulate global gene expression and diverse stage-specific functions to produce a continuous cycle of cellular events.