C
Clare Bycroft
Researcher at University of Oxford
Publications - 7
Citations - 5356
Clare Bycroft is an academic researcher from University of Oxford. The author has contributed to research in topics: Genome-wide association study & Neanderthal genome project. The author has an hindex of 7, co-authored 7 publications receiving 3029 citations. Previous affiliations of Clare Bycroft include Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
The UK Biobank resource with deep phenotyping and genomic data
Clare Bycroft,Colin Freeman,Desislava Petkova,Desislava Petkova,Gavin Band,Lloyd T. Elliott,Kevin Sharp,Allan Motyer,Damjan Vukcevic,Olivier Delaneau,Olivier Delaneau,Jared O'Connell,Adrian Cortes,Adrian Cortes,Samantha Welsh,Alan Young,Mark Effingham,Gil McVean,Stephen Leslie,Naomi E. Allen,Peter Donnelly,Jonathan Marchini +21 more
TL;DR: Deep phenotype and genome-wide genetic data from 500,000 individuals from the UK Biobank is described, describing population structure and relatedness in the cohort, and imputation to increase the number of testable variants to 96 million.
Posted ContentDOI
Genome-wide genetic data on ~500,000 UK Biobank participants
Clare Bycroft,Colin Freeman,Desislava Petkova,Lloyd T. Elliott,Kevin Sharp,Allan Motyer,Damjan Vukcevic,Olivier Delaneau,Jared O'Connell,Adrian Cortes,S Welsh,Gil McVean,Stephen Leslie,Peter Donnelly,Jonathan Marchini +14 more
TL;DR: The UK Biobank project is a large prospective cohort study of ~500,000 individuals from across the United Kingdom, aged between 40-69 at recruitment, and a set of analyses that reveal properties of the genetic data – such as population structure and relatedness – that can be important for downstream analyses are conducted.
Journal ArticleDOI
The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates.
Anjali Gupta Hinch,Philipp W. Becker,Tao Li,Tao Li,Daniela Moralli,Gang Zhang,Clare Bycroft,Catherine M. Green,Scott Keeney,Qinghua Shi,Benjamin Davies,Peter Donnelly +11 more
TL;DR: High-resolution in vivo maps of RPA and RAD51 in meiosis are reported, mapping their binding locations and lifespans to individual homologous chromosomes using a genetically engineered hybrid mouse, and the hypothesis that DMC1, not RAD51, performs strand exchange in mammalian meiosis is supported.
Journal ArticleDOI
Patterns of Genetic Differentiation and the Footprints of Historical Migrations in the Iberian Peninsula
Clare Bycroft,Ceres Fernandez-Rozadilla,Clara Ruiz-Ponte,Inés Quintela,Angel Carracedo,Peter Donnelly,Peter Donnelly,Simon Myers,Simon Myers +8 more
TL;DR: The genetic structure of the modern Iberian population is analysed at fine scale, revealing historical population movements associated with the time of Muslim rule and the subsequent Reconquista.
Journal ArticleDOI
Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe
Alessandro Raveane,Alessandro Raveane,Serena Aneli,Serena Aneli,Francesco Montinaro,Francesco Montinaro,Georgios Athanasiadis,Simona Barlera,Giovanni Birolo,Giorgio B. Boncoraglio,A. M. Di Blasio,C. Di Gaetano,Luca Pagani,Luca Pagani,Silvia Parolo,Peristera Paschou,Alberto Piazza,George Stamatoyannopoulos,Andrea Angius,Nicolas Brucato,Francesco Cucca,Garrett Hellenthal,Antonella Mulas,M. Peyret-Guzzon,Magdalena Zoledziewska,Abdellatif Baali,Clare Bycroft,Mohammed Cherkaoui,Jacques Chiaroni,J. Di Cristofaro,Christian Dina,Jean-Michel Dugoujon,Pilar Galan,Joanna Giemza,Toomas Kivisild,Toomas Kivisild,Stéphane Mazières,Mohammed Melhaoui,Mait Metspalu,Simon Myers,Luísa Pereira,François-Xavier Ricaut,Francesca Brisighelli,Irene Cardinali,Viola Grugni,Hovirag Lancioni,Vincenzo Lorenzo Pascali,Antonio Torroni,Ornella Semino,Giuseppe Matullo,Alessandro Achilli,Anna Olivieri,Cristian Capelli +52 more
TL;DR: In this paper, the authors characterize the ancestry profiles of Italian populations using a genome-wide dataset representative of modern and ancient samples from across Italy, Europe, and the rest of the world.