Peristera Paschou

TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.

TL;DR: Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.

TL;DR: This review summarizes the last decade of work by the ENIGMA Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease, and highlights the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings.

TL;DR: A novel algorithm is presented that is effectively used for the analysis of admixed populations without having to trace the origin of individuals, and can be easily applied on large genome-wide datasets, facilitating the identification of population substructure, stratification assessment in multi-stage whole-genome association studies, and the study of demographic history in human populations.

TL;DR: Gilles de la Tourette syndrome (GTS) is a childhood-onset neurodevelopmental disorder characterized by several motor and phonic tics as discussed by the authors, which usually develops before 10 years of age, exhibit a waxing and waning course and typically improve with increasing age.