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Claudia Saracini
Researcher at University of Florence
Publications - 26
Citations - 1057
Claudia Saracini is an academic researcher from University of Florence. The author has contributed to research in topics: Clopidogrel & CYP2C19. The author has an hindex of 15, co-authored 26 publications receiving 962 citations. Previous affiliations of Claudia Saracini include Utrecht University.
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Journal ArticleDOI
Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients.
Betti Giusti,Anna Maria Gori,Rossella Marcucci,Claudia Saracini,Ilaria Sestini,Rita Paniccia,Serafina Valente,D. Antoniucci,Rosanna Abbate,Gian Franco Gensini +9 more
TL;DR: This study demonstrates, for the first time, that the *2 CYP2C19 allele is associated with higher platelet aggregability and RPR in high-risk vascular patients on dual antiplatelet treatment.
Journal ArticleDOI
Relation of Cytochrome P450 2C19 Loss-of-Function Polymorphism to Occurrence of Drug-Eluting Coronary Stent Thrombosis
Betti Giusti,Anna Maria Gori,Rossella Marcucci,Claudia Saracini,Ilaria Sestini,Rita Paniccia,Piergiovanni Buonamici,David Antoniucci,Rosanna Abbate,Gian Franco Gensini +9 more
TL;DR: In this paper, the role of the CYP2C19*2 polymorphism in the occurrence of stent thrombosis or the composite end point of ST and cardiac mortality within a 6-month follow-up in patients undergoing percutaneous coronary interventions with drug-eluting stent implantation on dual-antiplatelet treatment enrolled in the RECLOSE trial.
Journal ArticleDOI
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
Gregory T. Jones,Gerard Tromp,Helena Kuivaniemi,Solveig Gretarsdottir,Annette F. Baas,Betti Giusti,Ewa Strauss,Femke N G van 't Hof,Tom R. Webb,Robert Erdman,Marylyn D. Ritchie,James R. Elmore,Anurag Verma,Sarah A. Pendergrass,Iftikhar J. Kullo,Zi Ye,Peggy L. Peissig,Omri Gottesman,Omri Gottesman,Shefali S. Verma,Jennifer Malinowski,Laura J. Rasmussen-Torvik,Kenneth M. Borthwick,Diane T. Smelser,David R. Crosslin,Mariza de Andrade,Evan J. Ryer,Catherine A. McCarty,E.P. Bottinger,Jennifer A. Pacheco,Dana C. Crawford,David Carrell,Glenn S. Gerhard,David P. Franklin,David J. Carey,Victoria L Phillips,Michael J.A. Williams,Wenhua Wei,Ross D. Blair,Andrew Hill,Thodor M. Vasudevan,David R. Lewis,Ian Thomson,J Krysa,Geraldine B. Hill,Justin A. Roake,Tony R. Merriman,Grzegorz Oszkinis,Silvia Galora,Claudia Saracini,Rosanna Abbate,Rosanna Abbate,Raffaele Pulli,Carlo Pratesi,Athanasios Saratzis,Ana Raquel Verissimo,Suzannah Bumpstead,Stephen A. Badger,Rachel E. Clough,Gillian Cockerill,Hany Hafez,D. Julian A. Scott,T. Simon Futers,Simon P. R. Romaine,Katherine I Bridge,Kathryn J. Griffin,Marc A. Bailey,Alberto Smith,Matthew M. Thompson,Frank M. van Bockxmeer,Stefan E Matthiasson,Gudmar Thorleifsson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Jan D. Blankensteijn,Joep A.W. Teijink,Joep A.W. Teijink,Cisca Wijmenga,Jacqueline de Graaf,Lambertus A. Kiemeney,Jes S. Lindholt,Anne Hughes,Declan Bradley,Kathleen Stirrups,Jonathan Golledge,Paul Norman,Janet T. Powell,Steve E. Humphries,Stephen E. Hamby,Alison H. Goodall,Christopher P. Nelson,Natzi Sakalihasan,Audrey Courtois,Robert E. Ferrell,Per Eriksson,Lasse Folkersen,Anders Franco-Cereceda,John D. Eicher,Andrew D. Johnson,Christer Betsholtz,Arno Ruusalepp,Arno Ruusalepp,Oscar Franzén,Oscar Franzén,Eric E. Schadt,Johan Björkegren,Leonard Lipovich,Leonard Lipovich,Anne M. Drolet,Eric L. G. Verhoeven,Clark J. Zeebregts,Robert H. Geelkerken,Marc R.H.M. van Sambeek,Steven M.M. van Sterkenburg,Jean-Paul P.M. de Vries,K. Stefansson,John R. Thompson,Paul I.W. de Bakker,Panos Deloukas,Robert D. Sayers,Seamus C. Harrison,Andre M. van Rij,Nilesh J. Samani,Matthew J. Bown +123 more
TL;DR: The 4 new risk loci for AAA seem to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease.
Journal ArticleDOI
Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm
Betti Giusti,Claudia Saracini,Paola Bolli,Alberto Magi,Ilaria Sestini,Elena Sticchi,Giovanni Pratesi,Raffaele Pulli,Carlo Pratesi,Rosanna Abbate +9 more
TL;DR: After haplotype reconstruction, logistic regression analyses adjusted for traditional risk factors and COPD showed a significant association among AAA and AHCY, FOLH 1, MTHFD1, MTR, NNMT, PON1 and TYMS haplotypes, offering new insights into the pathogenesis of AAA.
Journal ArticleDOI
Polymorphisms of genes involved in extracellular matrix remodeling and abdominal aortic aneurysm
Claudia Saracini,Paola Bolli,Elena Sticchi,Giovanni Pratesi,Raffaele Pulli,Francesco Sofi,Carlo Pratesi,Gian Franco Gensini,Rosanna Abbate,Betti Giusti +9 more
TL;DR: These findings suggest that polymorphisms in MMP2, M MP3, MMP-13, and ELN genes may independently contribute to the pathogenesis of abdominal aortic aneurysm and be a strong and independent determinant of AAA disease.