D
Diane T. Smelser
Researcher at Geisinger Health System
Publications - 41
Citations - 1870
Diane T. Smelser is an academic researcher from Geisinger Health System. The author has contributed to research in topics: Population & Abdominal aortic aneurysm. The author has an hindex of 19, co-authored 40 publications receiving 1174 citations. Previous affiliations of Diane T. Smelser include American Society of Human Genetics & Geisinger Medical Center.
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Journal ArticleDOI
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Sonia Shah,Albert Henry,Carolina Roselli,Honghuang Lin,G Sveinbjörnsson,Ghazaleh Fatemifar,Åsa K. Hedman,Jemma B. Wilk,Morley Mp,Mark Chaffin,Anna Helgadottir,Niek Verweij,Niek Verweij,Abbas Dehghan,Peter Almgren,C. Andersson,Krishna G. Aragam,Krishna G. Aragam,Johan Ärnlöv,Johan Ärnlöv,Joshua D. Backman,Mary L. Biggs,Heather L. Bloom,Jeff Brandimarto,Michael R. Brown,Leonard Buckbinder,David J. Carey,Daniel I. Chasman,Xu Chen,Jonathan H. Chung,William A. Chutkow,James P. Cook,Graciela E. Delgado,Spiros Denaxas,Alex S. F. Doney,Marcus Dörr,Samuel C. Dudley,Michael E. Dunn,Gunnar Engström,T Esko,T Esko,Stephan B. Felix,Chris Finan,Ian Ford,Mohsen Ghanbari,Sahar Ghasemi,Vilmantas Giedraitis,Franco Giulianini,John S. Gottdiener,Stefan Gross,Daníel F. Guðbjartsson,Daníel F. Guðbjartsson,Rebecca Gutmann,Christopher M. Haggerty,P. van der Harst,Craig L. Hyde,Erik Ingelsson,Joop Jukema,Maryam Kavousi,Khaw K-T.,Marcus E. Kleber,Lars Køber,Andrea Koekemoer,Claudia Langenberg,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Barry London,Luca A. Lotta,Ruth C. Lovering,Jian'an Luan,Patrick K.E. Magnusson,Anubha Mahajan,Kenneth B. Margulies,März W,März W,März W,Olle Melander,Ify R. Mordi,Thomas M. Morgan,Thomas M. Morgan,Andrew D. Morris,Andrew P. Morris,Alanna C. Morrison,Michael W. Nagle,Christopher P. Nelson,Alexander Niessner,Teemu J. Niiranen,Teemu J. Niiranen,Michelle L. O'Donoghue,Anjali T. Owens,Palmer Cna.,Helen M. Parry,Markus Perola,Eliana Portilla-Fernandez,Bruce M. Psaty,Kenneth Rice,Paul M. Ridker,Paul M. Ridker,Romaine Spr.,Jerome I. Rotter,Perttu Salo,Veikko Salomaa,J. van Setten,Alaa Shalaby,Diane T. Smelser,Nicholas L. Smith,Steen Stender,David J. Stott,Per Svensson,Tammesoo M-L.,Kent D. Taylor,Maris Teder-Laving,Alexander Teumer,Guðmundur Thorgeirsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Christian Torp-Pedersen,Stella Trompet,Benoit Tyl,André G. Uitterlinden,André G. Uitterlinden,Abirami Veluchamy,Uwe Völker,Adriaan A. Voors,Xianyuan Wang,Nicholas J. Wareham,Dawn M. Waterworth,P.E Weeke,Raul Weiss,Kerri L. Wiggins,Huilin Xing,Laura M. Yerges-Armstrong,Bing Yu,Faiez Zannad,Jing Hua Zhao,Harry Hemingway,Nilesh J. Samani,McMurray Jjv.,Jian Yang,Peter M. Visscher,Christopher Newton-Cheh,Christopher Newton-Cheh,Anders Mälarstig,Anders Mälarstig,Hilma Holm,Steven A. Lubitz,Steven A. Lubitz,Naveed Sattar,Michael V. Holmes,Michael V. Holmes,Michael V. Holmes,Thomas P. Cappola,Folkert W. Asselbergs,Folkert W. Asselbergs,Aroon D. Hingorani,Karoline Kuchenbaecker,Patrick T. Ellinor,Patrick T. Ellinor,Chim C. Lang,Kari Stefansson,Kari Stefansson,J. G. Smith,J. G. Smith,Ramachandran S. Vasan,Daniel I. Swerdlow,R. T. Lumbers +167 more
TL;DR: Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension.
Journal ArticleDOI
The Geisinger MyCode community health initiative: an electronic health record-linked biobank for precision medicine research.
David J. Carey,Samantha N. Fetterolf,F. Daniel Davis,William A. Faucett,H. Lester Kirchner,Uyenlinh L. Mirshahi,Michael F. Murray,Diane T. Smelser,Glenn S. Gerhard,David H. Ledbetter +9 more
TL;DR: The MyCode project has created resources that enable a new model for translational research that is faster, more flexible, and more cost-effective than traditional clinical research approaches.
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Sonia Shah,Albert Henry,Carolina Roselli,Honghuang Lin,Gardar Sveinbjornsson,Ghazaleh Fatemifar,Åsa K. Hedman,Jemma B. Wilk,Michael Morley,Mark Chaffin,Anna Helgadottir,Niek Verweij,Abbas Dehghan,Peter Almgren,Charlotte Andersson,Krishna G. Aragam,Johan Ärnlöv,Joshua D. Backman,Mary L. Biggs,Heather L. Bloom,Jeffrey Brandimarto,Michael R. Brown,Leonard Buckbinder,David J. Carey,Daniel I. Chasman,Xing Chen,Xu Chen,Jonathan H. Chung,William A. Chutkow,James P. Cook,Graciela E. Delgado,Spiros Denaxas,Alex S. F. Doney,Marcus Doerr,Samuel C. Dudley,Michael E. Dunn,Gunnar Engström,Tõnu Esko,Stephan B. Felix,Chris Finan,Ian Ford,Mohsen Ghanbari,Sahar Ghasemi,Vilmantas Giedraitis,Franco Giulianini,John S. Gottdiener,Stefan Gross,Daniel F. Gudbjartsson,Rebecca Gutmann,Christopher M. Haggerty,Pim van der Harst,Craig L. Hyde,Erik Ingelsson,J. Wouter Jukema,Maryam Kavousi,Kay-Tee Khaw,Marcus E. Kleber,Lars Køber,Andrea Koekemoer,Claudia Langenberg,Lars Lind,Cecilia M. Lindgren,Barry London,Luca A. Lotta,Ruth C. Lovering,Jian'an Luan,Patrik K. E. Magnusson,Anubha Mahajan,Kenneth B. Margulies,Winfried Maerz,Olle Melander,Ify R. Mordi,Thomas M. Morgan,Andrew D. Morris,Andrew P. Morris,Alanna C. Morrison,Michael W. Nagle,Christopher P. Nelson,Alexander Niessner,Teemu J. Niiranen,Michelle L. O'Donoghue,Anjali T. Owens,Colin N. A. Palmer,Helen M. Parry,Markus Perola,Eliana Portilla-Fernandez,Bruce M. Psaty,Kenneth Rice,Paul M. Ridker,Simon P. R. Romaine,Jerome I. Rotter,Perttu Salo,Veikko Salomaa,Jessica van Setten,Alaa Shalaby,Diane T. Smelser,Nicholas L. Smith,Steen Stender,David J. Stott,Per Svensson,Mari-Liis Tammesoo,Kent D. Taylor,Maris Teder-Laving,Alexander Teumer,Gudmundur Thorgeirsson,Unnur Thorsteinsdottir,Christian Torp-Pedersen,Stella Trompet,Benoit Tyl,André G. Uitterlinden,Abirami Veluchamy,Uwe Voelker,Adriaan A. Voors,Xiaosong Wang,Nicholas J. Wareham,Dawn M. Waterworth,Peter Weeke,Raul Weiss,Kerri L. Wiggins,Heming Xing,Laura M. Yerges-Armstrong,Bing Yu,Faiez Zannad,Jing Hua Zhao,Harry Hemingway,Nilesh J. Samani,John J.V. McMurray,Jian Yang,Peter M. Visscher,Christopher Newton-Cheh,Anders Mälarstig,Hilma Holm,Steven A. Lubitz,Naveed Sattar,Michael V. Holmes,Thomas P. Cappola,Folkert W. Asselbergs,Aroon D. Hingorani,Karoline Kuchenbaecker,Patrick T. Ellinor,Chim C. Lang,Kari Stefansson,J. Gustav Smith,Ramachandran S. Vasan,Daniel I. Swerdlow,R. Thomas Lumbers,Gonçalo R. Abecasis,Joshua D. Backman,Xiaodong Bai,Suganthi Balasubramanian,Nilanjana Banerjee,Aris Baras,Leland Barnard,Christina Beechert,Andrew Blumenfeld,Michael N. Cantor,Yating Chai,Giovanni Coppola,Amy Damask,Frederick E. Dewey,Aris N. Economides,Gisu Eom,Caitlin Forsythe,Erin D. Fuller,Zhenhua Gu,Lauren Gurski,Paloma M. Guzzardo,Lukas Habegger,Young Hahn,Alicia Hawes,Cristopher V. Van Hout,Marcus B. Jones,Shareef Khalid,Michael Lattari,Alexander H. Li,Nan Lin,Daren Liu,Alexander Lopez,Kia Manoochehri,Jonathan Marchini,Anthony Marcketta,Evan Maxwell,Shane A. McCarthy,Lyndon J. Mitnaul,Colm O'Dushlaine,John D. Overton,Maria Sotiropoulos Padilla,Charles Paulding,John Penn,Manasi Pradhan,Jeffrey G. Reid,Thomas D. Schleicher,Claudia Schurmann,Alan R. Shuldiner,Jeffrey Staples,Dylan Sun,Karina Toledo,Ricardo H. Ulloa,Louis Widom,Sarah E. Wolf,Ashish Yadav,Bin Ye +201 more
TL;DR: In this paper, the authors report results from a genome-wide association studies (GWAS) meta-analysis of heart failure comprising 47,309 cases and 930,014 controls.
Journal ArticleDOI
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
Gregory T. Jones,Gerard Tromp,Helena Kuivaniemi,Solveig Gretarsdottir,Annette F. Baas,Betti Giusti,Ewa Strauss,Femke N G van 't Hof,Tom R. Webb,Robert Erdman,Marylyn D. Ritchie,James R. Elmore,Anurag Verma,Sarah A. Pendergrass,Iftikhar J. Kullo,Zi Ye,Peggy L. Peissig,Omri Gottesman,Omri Gottesman,Shefali S. Verma,Jennifer Malinowski,Laura J. Rasmussen-Torvik,Kenneth M. Borthwick,Diane T. Smelser,David R. Crosslin,Mariza de Andrade,Evan J. Ryer,Catherine A. McCarty,E.P. Bottinger,Jennifer A. Pacheco,Dana C. Crawford,David Carrell,Glenn S. Gerhard,David P. Franklin,David J. Carey,Victoria L Phillips,Michael J.A. Williams,Wenhua Wei,Ross D. Blair,Andrew Hill,Thodor M. Vasudevan,David R. Lewis,Ian Thomson,J Krysa,Geraldine B. Hill,Justin A. Roake,Tony R. Merriman,Grzegorz Oszkinis,Silvia Galora,Claudia Saracini,Rosanna Abbate,Rosanna Abbate,Raffaele Pulli,Carlo Pratesi,Athanasios Saratzis,Ana Raquel Verissimo,Suzannah Bumpstead,Stephen A. Badger,Rachel E. Clough,Gillian Cockerill,Hany Hafez,D. Julian A. Scott,T. Simon Futers,Simon P. R. Romaine,Katherine I Bridge,Kathryn J. Griffin,Marc A. Bailey,Alberto Smith,Matthew M. Thompson,Frank M. van Bockxmeer,Stefan E Matthiasson,Gudmar Thorleifsson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Jan D. Blankensteijn,Joep A.W. Teijink,Joep A.W. Teijink,Cisca Wijmenga,Jacqueline de Graaf,Lambertus A. Kiemeney,Jes S. Lindholt,Anne Hughes,Declan Bradley,Kathleen Stirrups,Jonathan Golledge,Paul Norman,Janet T. Powell,Steve E. Humphries,Stephen E. Hamby,Alison H. Goodall,Christopher P. Nelson,Natzi Sakalihasan,Audrey Courtois,Robert E. Ferrell,Per Eriksson,Lasse Folkersen,Anders Franco-Cereceda,John D. Eicher,Andrew D. Johnson,Christer Betsholtz,Arno Ruusalepp,Arno Ruusalepp,Oscar Franzén,Oscar Franzén,Eric E. Schadt,Johan Björkegren,Leonard Lipovich,Leonard Lipovich,Anne M. Drolet,Eric L. G. Verhoeven,Clark J. Zeebregts,Robert H. Geelkerken,Marc R.H.M. van Sambeek,Steven M.M. van Sterkenburg,Jean-Paul P.M. de Vries,K. Stefansson,John R. Thompson,Paul I.W. de Bakker,Panos Deloukas,Robert D. Sayers,Seamus C. Harrison,Andre M. van Rij,Nilesh J. Samani,Matthew J. Bown +123 more
TL;DR: The 4 new risk loci for AAA seem to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease.
Journal ArticleDOI
Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.
Seung Hoan Choi,Lu-Chen Weng,Lu-Chen Weng,Carolina Roselli,Honghuang Lin,Christopher M. Haggerty,M. Benjamin Shoemaker,John Barnard,Dan E. Arking,Daniel I. Chasman,Daniel I. Chasman,Christine M. Albert,Mark Chaffin,Nathan R. Tucker,Nathan R. Tucker,Jonathan D. Smith,Namrata Gupta,Stacey Gabriel,Lauren Margolin,Marisa A. Shea,Christian M. Shaffer,Zachary T. Yoneda,Eric Boerwinkle,Nicholas L. Smith,Edwin K. Silverman,Susan Redline,Ramachandran S. Vasan,Esteban G. Burchard,Stephanie M. Gogarten,Cecelia A. Laurie,Thomas W. Blackwell,Gonçalo R. Abecasis,David J. Carey,Brandon K. Fornwalt,Diane T. Smelser,Aris Baras,Frederick E. Dewey,Cashell E. Jaquish,George J. Papanicolaou,Nona Sotoodehnia,David R. Van Wagoner,Bruce M. Psaty,Sekar Kathiresan,Dawood Darbar,Alvaro Alonso,Susan R. Heckbert,Susan R. Heckbert,Mina K. Chung,Dan M. Roden,Emelia J. Benjamin,Michael F. Murray,Kathryn L. Lunetta,Steven A. Lubitz,Steven A. Lubitz,Patrick T. Ellinor,Patrick T. Ellinor +55 more
TL;DR: In a case-control study, there was a statistically significant association between an LOF variant in the TTN gene and early-onset AF, with the variant present in a small percentage of participants with early-ONSet AF (the case group).