C
Cristina Ivan
Researcher at University of Texas MD Anderson Cancer Center
Publications - 197
Citations - 12070
Cristina Ivan is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & microRNA. The author has an hindex of 51, co-authored 182 publications receiving 9540 citations. Previous affiliations of Cristina Ivan include University of Texas Health Science Center at Houston & Leibniz University of Hanover.
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Journal ArticleDOI
Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.
Martin Pichler,Martin Pichler,Verena Stiegelbauer,Petra Vychytilova-Faltejskova,Cristina Ivan,Hui Ling,Elke Winter,Xinna Zhang,Matthew Goblirsch,Annika Wulf-Goldenberg,Masahisa Ohtsuka,Johannes Haybaeck,Marek Svoboda,Yoshinaga Okugawa,Armin Gerger,Gerald Hoefler,Ajay Goel,Ondrej Slaby,George A. Calin +18 more
TL;DR: In this article, a systematic approach on a global scale to identify miRNAs as clinical outcome predictors and further validated them in the clinical and experimental setting was followed, which can be partly explained by its effect on MLLT4 expression and migration of cancer cells.
Journal ArticleDOI
Notch3 pathway alterations in ovarian cancer
Wei Hu,Tao Liu,Cristina Ivan,Yunjie Sun,Jie Huang,Lingegowda S. Mangala,Takahito Miyake,Heather J. Dalton,Sunila Pradeep,Rajesha Rupaimoole,Rebecca A. Previs,Hee Dong Han,Justin Bottsford-Miller,Behrouz Zand,Yu Kang,Chad V. Pecot,Alpa M. Nick,Sherry Y. Wu,Ju Seog Lee,Vasudha Sehgal,Prahlad T. Ram,Jinsong Liu,Susan L. Tucker,Gabriel Lopez-Berestein,Keith A. Baggerly,Robert L. Coleman,Anil K. Sood +26 more
TL;DR: It is found that dynamin-mediated endocytosis was required for selectively activating Jagged-1-mediated Notch3 signaling and Cleaved Notch 3 expression was the critical determinant of response to Notch-targeted therapy.
Journal ArticleDOI
Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer
Vianey Gonzalez-Villasana,Enrique Fuentes-Mattei,Cristina Ivan,Heather J. Dalton,Cristian Rodriguez-Aguayo,Ricardo J. Fernandez-de Thomas,Burcu Aslan,Paloma Monroig,Paloma Monroig,Guermarie Velazquez-Torres,Rebecca A. Previs,Sunila Pradeep,Nermin Kahraman,Huamin Wang,Pinar Kanlikilicer,Bulent Ozpolat,George A. Calin,Anil K. Sood,Gabriel Lopez-Berestein +18 more
TL;DR: In vivo, zoledronic acid reduced tumor growth, angiogenesis, and cell proliferation and inactivated Rac1 in both HeyA8-MDR and OVCAR-5 models and were enhanced in both models when zoledronics acid was combined with nab-paclitaxel.
Journal ArticleDOI
ATP11B mediates platinum resistance in ovarian cancer.
Myrthala Moreno-Smith,Jyotsnabaran Halder,Paul S. Meltzer,Tamas A. Gonda,Lingegowda S. Mangala,Rajesha Rupaimoole,Chunhua Lu,Archana S. Nagaraja,Kshipra M. Gharpure,Yu Kang,Cristian Rodriguez-Aguayo,Pablo E. Vivas-Mejia,Behrouz Zand,Rosemarie Schmandt,Hua Wang,Robert R. Langley,Nicholas B. Jennings,Cristina Ivan,Jeremy E. Coffin,Guillermo N. Armaiz,Justin Bottsford-Miller,Sang Bae Kim,Margaret S. Halleck,Mary J.C. Hendrix,William Bornman,Menashe Bar-Eli,Ju Seog Lee,Zahid H. Siddik,Gabriel Lopez-Berestein,Anil K. Sood +29 more
TL;DR: It is found that inhibition of ATP11B expression could serve as a therapeutic strategy to overcome cisplatin resistance and was correlated with higher tumor grade in human ovarian cancer samples and with cis platin resistance inhuman ovarian cancer cell lines.
Journal ArticleDOI
MALAT1 promoted invasiveness of gastric adenocarcinoma.
Na Keum Lee,Jung Hwa Lee,Cristina Ivan,Hui Ling,Xinna Zhang,Chan Hyuk Park,George A. Calin,Sang Kil Lee +7 more
TL;DR: The study found that deregulation of MALAT1 could be involved in both tumorigenesis and invasiveness in gastric cancer cells, and examined mechanisms of invasion and metastasis.