C
Cristina Ivan
Researcher at University of Texas MD Anderson Cancer Center
Publications - 197
Citations - 12070
Cristina Ivan is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & microRNA. The author has an hindex of 51, co-authored 182 publications receiving 9540 citations. Previous affiliations of Cristina Ivan include University of Texas Health Science Center at Houston & Leibniz University of Hanover.
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Journal ArticleDOI
Epigenetic analysis of the Notch superfamily in high-grade serous ovarian cancer
Cristina Ivan,Wei Hu,Justin Bottsford-Miller,Behrouz Zand,Heather J. Dalton,Tao Liu,Jie Huang,Alpa M. Nick,Gabriel Lopez-Berestein,Robert L. Coleman,Keith A. Baggerly,Anil K. Sood +11 more
TL;DR: Epigenetic alterations of multiple Notch target genes and pathway interacting genes (PPARG, CCND1, and RUNX1) may relate to activation of this pathway and poor survival of patients with HGS-OvCa.
Journal ArticleDOI
ApoptomiRs expression modulated by BCR-ABL is linked to CML progression and imatinib resistance
Aline Fernanda Ferreira,L. G. Moura,I. Tojal,Luciana Ambrósio,B. Pinto-Simões,Nelson Hamerschlak,George A. Calin,Cristina Ivan,Dimas Tadeu Covas,Simone Kashima,Fabíola Attié de Castro +10 more
TL;DR: This study showed the modulation of apoptomiRs by BCR-ABL kinase activity and the deregulation of apoptotic target genes in different CML phases and after treatment with TK inhibitors.
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PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis.
Cristian Rodriguez-Aguayo,Emine Bayraktar,Cristina Ivan,Burcu Aslan,Junhua Mai,Guangan He,Lingegowda S. Mangala,Dahai Jiang,Archana S. Nagaraja,Bulent Ozpolat,Arturo Chavez-Reyes,Mauro Ferrari,Rahul Mitra,Zahid H. Siddik,Haifa Shen,Xianbin Yang,Anil K. Sood,Gabriel Lopez-Berestein +17 more
TL;DR: These findings identify PTGER3 as a potential therapeutic target in chemoresistant ovarian cancers expressing high levels of this oncogenic protein.
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Funcpep: A database of functional peptides encoded by non-coding rnas
Mihnea P. Dragomir,Mihnea P. Dragomir,Ganiraju C. Manyam,Leonie Florence Ott,Leonie Florence Ott,Lea Berland,Erik Knutsen,Cristina Ivan,Cristina Ivan,Leonard Lipovich,Bradley M. Broom,George A. Calin,George A. Calin +12 more
TL;DR: FuncPEP is developed, a new database of functional ncRNA encoded peptides, containing all experimentally validated and functionally characterized ncPEPs, and is believed to serve as a platform for further deciphering the biologic significance and medical use of nc PEPs.
Journal ArticleDOI
Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.
Zahra Timsah,Zahra Timsah,Zamal Ahmed,Cristina Ivan,Jonathan Berrout,Jonathan Berrout,Mihai Gagea,Yong Zhou,Guillermo N. Armaiz Pena,Xin Hu,Courtney Vallien,Charles V. Kingsley,Yiling Lu,John F. Hancock,Jinsong Liu,Andrew B. Gladden,Gordon B. Mills,Gabriel Lopez-Berestein,Mien Chie Hung,Anil K. Sood,Mikhail Bogdanov,John E. Ladbury,John E. Ladbury +22 more
TL;DR: Oncogenesis through fluctuation in the expression levels of these proteins negates extracellular stimulation or mutation and defines them as novel prognostic markers in ovarian cancer.