C
Cristina Ivan
Researcher at University of Texas MD Anderson Cancer Center
Publications - 197
Citations - 12070
Cristina Ivan is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & microRNA. The author has an hindex of 51, co-authored 182 publications receiving 9540 citations. Previous affiliations of Cristina Ivan include University of Texas Health Science Center at Houston & Leibniz University of Hanover.
Papers
More filters
Journal ArticleDOI
miR-203 Induces Oxaliplatin Resistance in Colorectal Cancer Cells by Negatively Regulating ATM Kinase
Yunfei Zhou,Guohui Wan,Riccardo Spizzo,Cristina Ivan,Rohit Mathur,Xiaoxiao Hu,Xiangcang Ye,Jia Lu,Fan Fan,Ling Xia,George A. Calin,Lee M. Ellis,Xiongbin Lu +12 more
TL;DR: This is the first report of oxaliplatin resistance in CRC cells induced by miR‐203‐mediated suppression of ATM, and stable knockdown of ATM induced resistance to oxali Platin in chemo‐naïve CRC cells.
Journal ArticleDOI
Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment.
Masato Nishimura,Masato Nishimura,Eun-Jung Jung,Eun-Jung Jung,Maitri Y. Shah,Chunhua Lu,Riccardo Spizzo,Masayoshi Shimizu,Hee Dong Han,Cristina Ivan,Simona Rossi,Simona Rossi,Xinna Zhang,Milena S. Nicoloso,Sherry Y. Wu,Maria Inês Almeida,Justin Bottsford-Miller,Chad V. Pecot,Behrouz Zand,Koji Matsuo,Mian M.K. Shahzad,Mian M.K. Shahzad,Nicholas B. Jennings,Cristian Rodriguez-Aguayo,Gabriel Lopez-Berestein,Anil K. Sood,George A. Calin +26 more
TL;DR: Combined targeting of the Eph pathway using EphA2-targeting siRNA and the tumor suppressor miR-520d-3p exhibits remarkable therapeutic synergy and enhanced tumor suppression in vitro and in vivo compared with either monotherapy alone.
Journal ArticleDOI
Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2
Roxana S. Redis,Luz E. Vela,Weiqin Lu,Juliana Ferreira de Oliveira,Cristina Ivan,Cristian Rodriguez-Aguayo,Douglas Adamoski,Barbara Pasculli,Ayumu Taguchi,Yunyun Chen,Agustín F. Fernández,Luis Valledor,Katrien Van Roosbroeck,Samuel Chang,Maitri Y. Shah,Garrett Kinnebrew,Leng Han,Yaser Atlasi,Lawrence H. Cheung,Gilbert Yuanjay Huang,Paloma Monroig,Marc S. Ramirez,Tina Catela Ivković,Long Van,Hui Ling,Roberta Gafà,Sanja Kapitanović,Giovanni Lanza,James A. Bankson,Peng Huang,Stephan Y. Lai,Robert C. Bast,Michael G. Rosenblum,Milan Radovich,Mircea Ivan,Geoffrey Bartholomeusz,Han Liang,Mario F. Fraga,William R. Widger,Samir M. Hanash,Ioana Berindan-Neagoe,Ioana Berindan-Neagoe,Ioana Berindan-Neagoe,Gabriel Lopez-Berestein,Andre Luis Berteli Ambrosio,Sandra Martha Gomes Dias,George A. Calin +46 more
TL;DR: The CCAT2 interaction with the CFIm complex fine-tunes the alternative splicing of Glutaminase (GLS) by selecting the poly(A) site in intron 14 of the precursor mRNA.
Journal ArticleDOI
Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer
Pinar Kanlikilicer,Recep Bayraktar,Merve Denizli,Mohammed H. Rashed,Cristina Ivan,Burcu Aslan,Rahul Mitra,Kubra Karagoz,Emine Bayraktar,Xinna Zhang,Cristian Rodriguez-Aguayo,Amr Ahmed El-Arabey,Nermin Kahraman,Seyda Baydogan,Ozgur Ozkayar,Michael L. Gatza,Bulent Ozpolat,George A. Calin,Anil K. Sood,Gabriel Lopez-Berestein +19 more
TL;DR: A new mechanistic therapeutic approach is provided to overcome chemoresistance and tumor progression through exosomal miR-1246 in OC patients and suggests that cancer exosomes may contribute to oncogenesis by manipulating neighboring infiltrating immune cells.
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
Twan van den Beucken,Twan van den Beucken,Elizabeth Koch,Kenneth C. Chu,Rajesha Rupaimoole,Peggy Prickaerts,Michiel E. Adriaens,Michiel E. Adriaens,Jan Willem Voncken,Adrian L. Harris,Francesca M. Buffa,Syed Haider,Maud H.W. Starmans,Maud H.W. Starmans,Cindy Q. Yao,Cindy Q. Yao,Mircea Ivan,Cristina Ivan,Chad V. Pecot,Paul C. Boutros,Paul C. Boutros,Anil K. Sood,Marianne Koritzinsky,Bradly G. Wouters,Bradly G. Wouters,Bradly G. Wouters +25 more
TL;DR: In this article, the authors identify tumour hypoxia as a regulator of DICER expression in large cohorts of breast cancer patients and show that reduced expression of the enzyme leads to derepression of the miR200 target ZEB1, stimulates the epithelial to mesenchymal transition and ultimately results in the acquisition of stem cell phenotypes in human mammary epithelial cells.