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Andrea Schulz
Researcher at Greifswald University Hospital
Publications - 34
Citations - 2327
Andrea Schulz is an academic researcher from Greifswald University Hospital. The author has contributed to research in topics: Population & Study of Health in Pomerania. The author has an hindex of 18, co-authored 28 publications receiving 2035 citations. Previous affiliations of Andrea Schulz include University of Greifswald.
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Journal ArticleDOI
A mega-analysis of genome-wide association studies for major depressive disorder
Stephan Ripke,Naomi R. Wray,Cathryn M. Lewis,Steven P. Hamilton,Myrna M. Weissman,Gerome Breen,Enda M. Byrne,Douglas Blackwood,Dorret I. Boomsma,Sven Cichon,Andrew C. Heath,Florian Holsboer,Susanne Lucae,Pamela A. F. Madden,Nicholas G. Martin,Peter McGuffin,Pierandrea Muglia,Markus M. Noethen,Brenda P Penninx,Michele L. Pergadia,James B. Potash,Marcella Rietschel,Danyu Lin,Bertram Müller-Myhsok,Jianxin Shi,Stacy Steinberg,Hans J. Grabe,Paul Lichtenstein,Patrik K. E. Magnusson,Roy H. Perlis,Martin Preisig,Jordan W. Smoller,Kari Stefansson,Rudolf Uher,Zoltán Kutalik,Katherine E. Tansey,Alexander Teumer,Alexander Viktorin,Michael R. Barnes,Thomas Bettecken,Elisabeth B. Binder,René Breuer,Victor M. Castro,Susanne Churchill,William Coryell,Nicholas John Craddock,Ian W. Craig,Darina Czamara,Eco J. C. de Geus,Franziska Degenhardt,Anne Farmer,Maurizio Fava,Josef Frank,Vivian S. Gainer,Patience J. Gallagher,Scott D. Gordon,Sergey Goryachev,Magdalena Gross,Michel Guipponi,Anjali K. Henders,Stefan Herms,Ian B. Hickie,Susanne Hoefels,Witte J.G. Hoogendijk,Jouke-Jan Hottenga,Dan V. Iosifescu,Marcus Ising,Ian Jones,Lisa Jones,Tzeng Jung-Ying,James A. Knowles,Isaac S. Kohane,Martin A. Kohli,Ania Korszun,Mikael Landén,William Lawson,Glyn Lewis,Donald J. MacIntyre,Wolfgang Maier,Manuel Mattheisen,Patrick J. McGrath,Andrew M. McIntosh,Alan W. McLean,Christel M. Middeldorp,Lefkos T. Middleton,G. M. Montgomery,Shawn N. Murphy,Matthias Nauck,Willem A. Nolen,Dale R. Nyholt,Michael Conlon O'Donovan,Hogni Oskarsson,Nancy L. Pedersen,William A. Scheftner,Andrea Schulz,Thomas G Schulze,Stanley I. Shyn,Engilbert Sigurdsson,Susan L. Slager,Johannes H. Smit,Hreinn Stefansson,Michael Steffens,Thorgeir E. Thorgeirsson,Federica Tozzi,Jens Treutlein,Manfred Uhr,Edwin J. C. G. van den Oord,Gerard van Grootheest,Henry Völzke,Jeffrey B. Weilburg,Gonneke Willemsen,Frans G. Zitman,Benjamin M. Neale,Mark J. Daly,Douglas F. Levinson,Patrick F. Sullivan +115 more
TL;DR: This article conducted a genome-wide association studies (GWAS) mega-analysis for major depressive disorder (MDD) using more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) in 18,759 independent and unrelated subjects of recent European ancestry.
Journal ArticleDOI
Moderation of Adult Depression by a Polymorphism in the FKBP5 Gene and Childhood Physical Abuse in the General Population
Katja Appel,Christian Schwahn,Christian Schwahn,Jessie Mahler,Andrea Schulz,Carsten Spitzer,Kristin Fenske,Jan P. Stender,Sven Barnow,Ulrich John,Alexander Teumer,Reiner Biffar,Matthias Nauck,Henry Völzke,Harald J. Freyberger,Hans J. Grabe +15 more
TL;DR: Interactions between physical abuse and rs1360780 of the FKBP5 gene, confirming its role in the individual susceptibility to depression, could be included into prediction models for depression in individuals exposed to childhood abuse.
Journal ArticleDOI
A Genome-Wide Association Study of Depressive Symptoms
Karin Hek,Ayse Demirkan,Jari Lahti,Jari Lahti,Antonio Terracciano,Alexander Teumer,Marilyn C. Cornelis,Najaf Amin,Erin Bakshis,Jens Baumert,Jingzhong Ding,Yongmei Liu,Kristin D. Marciante,Osorio Meirelles,Mike A. Nalls,Yan V. Sun,Nicole Vogelzangs,Lei Yu,Stefania Bandinelli,Emelia J. Benjamin,David A. Bennett,Dorret I. Boomsma,Alessandra Cannas,Laura H. Coker,Eco J. C. de Geus,Philip L. De Jager,Ana V. Diez-Roux,Shaun Purcell,Frank B. Hu,Eric B. Rimm,David J. Hunter,Majken K. Jensen,Gary C. Curhan,Kenneth Rice,Alan D. Penman,Jerome I. Rotter,Nona Sotoodehnia,Rebecca T. Emeny,Johan G. Eriksson,Denis A. Evans,Luigi Ferrucci,Myriam Fornage,Vilmundur Gudnason,Albert Hofman,Thomas Illig,Sharon L.R. Kardia,Margaret Kelly-Hayes,Karestan C. Koenen,Peter Kraft,Maris Kuningas,Joseph M. Massaro,David Melzer,Antonella Mulas,Cornelis L. Mulder,Anna Murray,Ben A. Oostra,Aarno Palotie,Brenda W.J.H. Penninx,Astrid Petersmann,Luke C. Pilling,Bruce M. Psaty,Rajesh Rawal,Eric M. Reiman,Andrea Schulz,Joshua M. Shulman,Andrew B. Singleton,Albert V. Smith,Angelina R. Sutin,Angelina R. Sutin,André G. Uitterlinden,Henry Völzke,Elisabeth Widen,Kristine Yaffe,Alan B. Zonderman,Francesco Cucca,Tamara B. Harris,Karl-Heinz Ladwig,David J. Llewellyn,Katri Räikkönen,Toshiko Tanaka,Cornelia M. van Duijn,Hans J. Grabe,Lenore J. Launer,Kathryn L. Lunetta,Thomas H. Mosley,Anne B. Newman,Henning Tiemeier,Joanne M. Murabito +87 more
TL;DR: The results suggest that only a large sample comprising more than 50,000 subjects may be sufficiently powered to detect genes for depressive symptoms, as well as a combined meta-analysis of all 22 discovery and replication studies.
Journal ArticleDOI
Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population
Hans J. Grabe,Christian Schwahn,Katja Appel,Jessie Mahler,Andrea Schulz,Carsten Spitzer,Kristin Fenske,Sven Barnow,Michael Lucht,Harald J. Freyberger,Ulrich John,Alexander Teumer,Henri Wallaschofski,Matthias Nauck,Henry Völzke +14 more
TL;DR: Although this study did not replicate the specific interaction of abuse and the TAT–haplotype of the CRHR1 gene, it confirmed the relevance of an interplay between variants within the CRH‐Receptor Gene and childhood adversities in the modulation of depression in adults.
Journal ArticleDOI
Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse
Hans J. Grabe,Christian Schwahn,Jessie Mahler,Katja Appel,Andrea Schulz,Carsten Spitzer,Kristin Fenske,Sven Barnow,Harald J. Freyberger,Alexander Teumer,Astrid Petersmann,Reiner Biffar,Dieter Rosskopf,Ulrich John,Henry Völzke +14 more
TL;DR: The results point to a gene-gene-environment interaction that relevantly impacts on the role of the s/s genotype of the 5-HTTLPR in childhood abuse: Depending on the BDNF background (Val/Val versus Met allele) the s-S genotype showed either protective or risk properties with regard to depressive symptoms.