Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation
Daniel F. Legler,Daniel F. Legler,Olivier Micheau,Marie-Agnès Doucey,Jürg Tschopp,Claude Bron +5 more
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TLDR
It is suggested that lipid rafts are crucial for the outcome of TNFalpha-activated signaling pathways, which leads to the degradation via the proteasome pathway.About:
This article is published in Immunity.The article was published on 2003-05-01 and is currently open access. It has received 430 citations till now. The article focuses on the topics: Lipid raft & TRADD.read more
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Journal ArticleDOI
Signaling to NF-kappaB.
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: An overview of established NF-kappaB signaling pathways is provided with focus on the current state of research into the mechanisms that regulate IKK activation and NF- kappaB transcriptional activity.
Journal ArticleDOI
Signalling pathways of the TNF superfamily: a double-edged sword.
TL;DR: Two different tumour-necrosis factors, first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice, and blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases.
Journal ArticleDOI
Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes
Olivier Micheau,Jürg Tschopp +1 more
TL;DR: TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal fails to be activated, and the cell survives.
Journal ArticleDOI
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
Ingrid E. Wertz,Karen O'Rourke,Honglin Zhou,Michael Eby,L. Aravind,Somasekar Seshagiri,Ping Wu,Christian Wiesmann,Rohan T. Baker,David L. Boone,Averil Ma,Eugene V. Koonin,Vishva M. Dixit +12 more
TL;DR: A novel ubiquitin ligase domain is defined and two sequential mechanisms by which A20 downregulates NF-κB signalling are identified, both of which participate in mediating a distinct regulatory effect.
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Tumor necrosis factor antagonist mechanisms of action: A comprehensive review
TL;DR: The biology of T NF and related family members are discussed in the context of the potential mechanisms of action of TNF antagonists in a variety of immune-mediated inflammatory diseases.
References
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Journal ArticleDOI
Lipid rafts and signal transduction
Kai Simons,Derek Toomre +1 more
TL;DR: It is now becoming clear that lipid micro-environments on the cell surface — known as lipid rafts — also take part in this process of signalling transduction, where protein–protein interactions result in the activation of signalling cascades.
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Death receptors: signaling and modulation
Avi Ashkenazi,Vishva M. Dixit +1 more
TL;DR: Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival.
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THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
TL;DR: The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases.
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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Michael Karin,Yinon Ben-Neriah +1 more
TL;DR: Recent progress has been made in understanding the details of the signaling pathways that regulate NF-kappaB activity, particularly those responding to the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1.
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The TNF and TNF receptor superfamilies: integrating mammalian biology.
TL;DR: The authors regret the inability to cite all of the primary literature contributing to this review due to length considerations, but wish to thank F. Chan, T. Migone, and J. Wang for insightful comments on the manuscript.
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Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes
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