The epigenetics of aging and neurodegeneration.
Roy Lardenoije,Artemis Iatrou,Gunter Kenis,Konstantinos Kompotis,Harry W.M. Steinbusch,Diego Mastroeni,Paul D. Coleman,Cynthia A. Lemere,Patrick R. Hof,Daniel L.A. van den Hove,Bart P. F. Rutten +10 more
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TLDR
Current knowledge about the major epigenetic mechanisms, including DNA methylation and DNA demethylation, chromatin remodeling and non-coding RNAs, as well as the involvement of these mechanisms in normal aging and in the pathophysiology of the most common neurodegenerative diseases are reviewed.About:
This article is published in Progress in Neurobiology.The article was published on 2015-08-01 and is currently open access. It has received 314 citations till now. The article focuses on the topics: Epigenetic regulation of neurogenesis & Epigenetics of schizophrenia.read more
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How neuroinflammation contributes to neurodegeneration.
TL;DR: Observations indicate that therapies targeting glial cells might provide benefit for those afflicted by neurodegenerative disorders, because the environment is affected during disease in a cascade of processes collectively termed neuroinflammation.
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Predicting Age Using Neuroimaging: Innovative Brain Ageing Biomarkers.
James H. Cole,Katja Franke +1 more
TL;DR: Evidence supporting the use of neuroimaging-based 'brain age' as a biomarker of an individual's brain health is presented and controversies surrounding brain age are discussed.
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Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies.
Goran Šimić,Mirjana Babić Leko,Selina Wray,Charles R. Harrington,Ivana Delalle,Nataša Jovanov-Milošević,Danira Bažadona,Luc Buée,Rohan de Silva,Giuseppe Di Giovanni,Giuseppe Di Giovanni,Claude M. Wischik,Patrick R. Hof +12 more
TL;DR: It is concluded that answering key questions on the relationship between Aβ and tau pathology should lead to a better understanding of the nature of secondary tauopathies, especially AD, and open new therapeutic targets and strategies.
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Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics
TL;DR: The present review discusses the current state of the art in AD therapeutics and diagnostics, including labeling and imaging techniques employed as contrast agents for better visualization and sensing of the plaques and points to an urgent need for nanotechnology as an efficient therapeutic strategy to increase the bioavailability of drugs in the central nervous system.
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β-Hydroxybutyrate: A Signaling Metabolite
John C. Newman,Eric Verdin +1 more
TL;DR: The ketone body β-hydroxybutyrate represents an essential carrier of energy from the liver to peripheral tissues when the supply of glucose is too low for the body's energetic needs, such as during periods of prolonged exercise, starvation, or absence of dietary carbohydrates.
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TL;DR: The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
Journal ArticleDOI
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
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The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
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TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
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