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David A. White
Researcher at Baker IDI Heart and Diabetes Institute
Publications - 17
Citations - 1011
David A. White is an academic researcher from Baker IDI Heart and Diabetes Institute. The author has contributed to research in topics: Macrophage migration inhibitory factor & Inflammation. The author has an hindex of 12, co-authored 17 publications receiving 862 citations. Previous affiliations of David A. White include Alfred Hospital & Monash University.
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Journal ArticleDOI
Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance
Michael J Kraakman,Helene L. Kammoun,Tamara L Allen,Virginie Deswaerte,Darren C. Henstridge,Emma Estevez,Vance B. Matthews,Bronwyn A Neill,David A. White,Andrew J. Murphy,Lone Peijs,Christine Yang,Steve Risis,Clinton R. Bruce,Xiao-Jun Du,Alex Bobik,Robert S. Lee-Young,Bronwyn A. Kingwell,Ajithkumar Vasanthakumar,Wei Shi,Wei Shi,Axel Kallies,Graeme I. Lancaster,Stefan Rose-John,Mark A. Febbraio +24 more
TL;DR: In this article, the authors show that IL-6 trans-signaling recruits macrophages into adipose tissue (ATM), but does not improve insulin action, and suggest that selectively blocking trans-Signaling with soluble gp130Fc protein may be a more favorable treatment option for inflammatory diseases.
Journal ArticleDOI
Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy
Lu Fang,Andris H. Ellims,Andris H. Ellims,Xiao-Lei Moore,David A. White,Andrew J. Taylor,Andrew J. Taylor,Jaye Chin-Dusting,Anthony M. Dart,Anthony M. Dart,Anthony M. Dart +10 more
TL;DR: Findings suggest that circulating miRNAs provide attractive candidates as putative biomarkers for diffuse myocardial fibrosis in HCM.
Journal ArticleDOI
Acute Left Ventricular Remodeling Following Myocardial Infarction : Coupling of Regional Healing With Remote Extracellular Matrix Expansion
William Chan,Stephen J. Duffy,Stephen J. Duffy,David A. White,Xiao-Ming Gao,Xiao-Jun Du,Andris H. Ellims,Andris H. Ellims,Anthony M. Dart,Anthony M. Dart,Anthony M. Dart,Andrew J. Taylor,Andrew J. Taylor +12 more
TL;DR: Within a week of acute MI, the remote myocardium exhibits systolic dysfunction and expansion of the ECM, which is coupled with physiological infarct healing, suggesting a coupling of regional healing with acute LV remodeling.
Journal ArticleDOI
Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation.
Xiao-Ming Gao,Yang Liu,David A. White,Yidan Su,Brian G. Drew,Clinton R. Bruce,Helen Kiriazis,Qi Xu,N. Jennings,Alex Bobik,Mark A. Febbraio,Bronwyn A. Kingwell,Richard Bucala,Gunter Fingerle-Rowson,Anthony M. Dart,Eric F Morand,Xiao-Jun Du +16 more
TL;DR: It is shown that duration of both ischemia and reperfusion is a determinant for the degree of regional inflammation and tissue damage and MIF inhibitory therapy may be a novel strategy to protect the heart against severe I/R injury.
Journal ArticleDOI
Post-infarct cardiac rupture: recent insights on pathogenesis and therapeutic interventions.
Xiao-Ming Gao,David A. White,Anthony M. Dart,Anthony M. Dart,Anthony M. Dart,Xiao-Jun Du,Xiao-Jun Du +6 more
TL;DR: These findings convincingly demonstrate that cardiac inflammation, damage to extracellular matrix proteins or blunted fibrotic healing constitute the central mechanisms for the pathogenesis of cardiac rupture and acute ventricular remodeling.